Research Fellow (Fixed Term)

Area

Translational Medical Sciences

Location

UK Other

Salary

£31,387 to £46,485 per annum, depending on skills and experience (minimum £35608 with relevant PhD).

Closing Date

Wednesday 03 June 2026

Reference

MED1212226

Applications are invited for a Research Fellow to work on a Medical Research Council-funded project investigating the role of ERG transcription factor as a master regulator of lymphatic identity and immune functionality. You will be part of a unique partnership between the University of Nottingham and Imperial College London, and will have the opportunity to collaborate with experts at City St. George’s, University of London.

You will employ in vivo models with state-of-the-art molecular and cellular assays to uncover how ERG operates as an "immune gatekeeper" during both steady-state and inflammatory challenges. Ultimately, your findings will define a new roadmap for therapeutic targets to treat debilitating conditions like primary lymphoedema, directly bridging the gap between fundamental molecular science and patient benefit.

About you: You will lead investigations into how the transcription factor ERG regulates lymphatic identity and immune cell trafficking. Your responsibilities will include performing in vivo functional assays to quantify lymphatic drainage and immune cell trafficking. You will utilize single-cell transcriptomics and high-resolution multiplexed imaging to map cellular landscapes in mouse and human tissues. Additionally, you will conduct mechanistic studies to identify the role of ERG in lymph node maintenance. Throughout, you will develop advanced analytical skills and benefit from a dynamic and collaborative research environment.

What we are looking for: Applicants must be highly motivated and self-driven, with a PhD in vascular biology, immunology, or cell biology to join this collaborative project, specifically looking for candidates who can demonstrate: The successful candidate will ideally have considerable experience in some of the following areas: in vivo immune and vascular techniques using genetically modified mice, high-resolution imaging, single-cell transcriptomics (scRNA-seq), strong analytical and computational abilities to interpret high-dimensional datasets, identify unique gene signatures, and predict cellular interactions.

The successful candidate will join a friendly, diverse, and supportive research group based in the Biodiscovery Institute. The position represents a significant opportunity through the provision of training, continued support, and career progression opportunities.

Further information is available in the role profile. To apply for this vacancy please click ‘Apply Now’ to complete your details.

This role will be offered on a fixed-term contract for 36 months. Your working hours will be (36.25 hours per week). If you are interested in part-time work (minimum 29 hours per week), we encourage you to apply. Please specify your preferred hours in your application. We may also consider job share arrangements.

Please contact Jacqueline.shields@nottingham.ac.uk if you have further questions about this role. Please note that applications sent directly to this email address will not be accepted.

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Job Description/Role Profile

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