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A Phase III Trial Of UCB4594 To Assess Safety, Pharmacokinetics, And Anti-Cancer Effects In Participants With Advanced Solid Tumors
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Actively Recruiting
Phase 1
Phase 2
Age: 18 Years +
All Genders
ID06380816
A Phase III Trial of UCB4594 to Assess Safety, Pharmacokinetics, and Anti-cancer Effects in Participants With Advanced Solid Tumors
Led by Cancer Research UK
Updated on 2026-05-08
167
Participants Needed
4
Research Sites
N/A
Total Duration
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AI-Summary
Brief Title
A Phase III Trial of UCB4594 to Assess Safety, Pharmacokinetics, and Anti-cancer Effects in Participants With Advanced Solid Tumors
Who Can Participate
Age: 18 Years +
All Genders
AI-Screening
AI-Powered Screening
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to approximately 1 year
Participants receive UCB4594 as an intravenous infusion once every 3 weeks for up to 18 cycles. This includes a dose escalation phase to find the best dose and a dose expansion phase to assess the drug's effects alone or in combination with other anti-cancer drugs.
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Up to 18 visits every 3 weeks (in-person)
Trial Site Locations
Total: 4 locations
- Guy's Hospital
- London, United Kingdom, SE1 9RT
- Actively Recruiting
- The Christie NHS Foundation Trust
- Manchester, United Kingdom
- Actively Recruiting
- The Newcastle upon Tyne Hospitals NHS Foundation Trust
- Newcastle upon Tyne, United Kingdom, NE7 7DN
- Actively Recruiting
- University Hospital Southampton NHS Foundation Trust
- Southampton, United Kingdom
- Not Yet Recruiting
Leaflet
Research Team
- Fiona Thistlethwaite, Prof
How is the study designed?
Study Type
- INTERVENTIONAL
Masking
- NONE
Allocation
- NON_RANDOMIZED
Model
- SEQUENTIAL
Primary Purpose
- TREATMENT
Number of Arms
- 2
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Frequently Asked Questions
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On this page
AI-Summary
Brief Title
A Phase III Trial of UCB4594 to Assess Safety, Pharmacokinetics, and Anti-cancer Effects in Participants With Advanced Solid Tumors
Who Can Participate
Age: 18 Years +
All Genders
AI-Screening
Your Study Journey
Trial Site Locations
Research Team
How is the study designed?
Similar Trials
Frequently Asked Questions
Sponsors
- Cancer Research UK
- Lead Sponsor
- UCB Biopharma SRL
- Collaborating Sponsor
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