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Associate Scientist / Research Scientist – Upstream Process Sciences
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About the Role
To strengthen our Drug Substance Process Sciences team, we are seeking a talented and motivated Associate Scientist / Research Scientist to support upstream process development for biologics.
You will contribute to early-stage process development, process optimisation, technology transfer, and manufacturing support activities. Working within a multidisciplinary team, you will help develop scalable mammalian cell culture processes, perform process characterisation and troubleshooting studies, and support the delivery of innovative protein therapeutics.
This is a laboratory-based role offering exposure to advanced cell culture technologies, high-throughput platforms, and bioreactor systems ranging from microscale to pilot scale.
Your Activities
Process Development & Laboratory Operations
- Design, plan, and execute upstream process development studies with minimal supervision.
- Apply QbD and DoE approaches to process optimisation and characterisation.
- Perform mammalian cell culture experiments using shake flasks, Ambr® systems, and laboratory-scale bioreactors.
- Support scale-up, scalability assessments, process troubleshooting, and technology transfer activities.
- Utilise automation and high-throughput technologies to improve workflow efficiency.
- Contribute to evaluation of emerging technologies and platform improvements.
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Data Analysis & Scientific Communication
- Analyse and interpret experimental data using appropriate statistical approaches.
- Generate accurate, high-quality scientific data and documentation.
- Prepare technical reports, protocols, presentations, and project summaries.
- Communicate findings and recommendations to project teams and stakeholders.
Collaboration & Compliance
- Collaborate with Cell Line Development, Analytical Sciences, Downstream Development, Manufacturing and external partners.
- Represent Upstream Process Sciences in cross-functional project teams.
- Maintain accurate laboratory records and electronic laboratory notebooks.
- Ensure compliance with HSE, GMP/GSP, quality systems, and data integrity requirements.
- Participate in continuous improvement initiatives and laboratory best practices.
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Requirements
- MSc in Biotechnology, Biochemical Engineering, Chemical Engineering, Molecular Biology, Cell Biology, Bioprocess Engineering, or related discipline. or BSc with relevant industrial experience.
Technical Skills & Experience
- Experience in mammalian cell culture and biologics process development.
- Hands-on experience with CHO cell culture and therapeutic protein production.
- Experience operating Ambr® and/or laboratory-scale bioreactor systems.
- Knowledge of cell culture scale-up principles and process characterisation.
- Experience applying DoE and statistical data analysis tools.
- Strong scientific problem-solving and troubleshooting skills.
- Experience with automation, digital tools, and data management systems.
- Understanding of GMP, data integrity, and quality requirements.
Advantageous
- Perfusion or ATF process experience.
- Technology transfer and manufacturing support experience.
- Exposure to downstream processing and integrated process development.
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