Hlx Life Sciences
Associate Scientist/Technician - CNS Biology
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Associate Scientist/Technician - CNS Biology
We are seeking a highly motivated Associate Scientist/Technician to join our CNS Biology team. This laboratory-based role will focus on conducting in vitro studies using human iPSC-derived neuronal models to support the discovery and development of novel therapeutics.
Role Overview
The role will report to the Associate Director, Biology and involve:
- Establish, maintain and differentiate human iPSC-derived neuronal cultures, supporting their maturation and ongoing maintenance for compound screening and mechanistic studies.
- Perform routine hands-on culture of iPSC-derived neurons, including cell seeding, media preparation, differentiation, maturation, passaging where appropriate, cryopreservation, thawing and quality control.
- Support pharmacological studies, including compound preparation, dose-response experiments and analysis of treatment effects using biochemical and cellular assays including ELISA, Western blotting and immunocytochemistry.
- Support the development and optimisation of robust neuronal cellular models and assays for CNS drug discovery.
- Maintain high standards of laboratory organisation, reagent preparation, equipment maintenance and inventory management.
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This is primarily a lab-based role (>75%), with the expectation of being onsite in Hammersmith for a minimum of four days per week.
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Qualifications & Experience
- BSc or MSc in a relevant biological discipline, such as neuroscience, biochemistry, pharmacology, genetics or a related field.
- Substantial hands-on experience culturing and maintaining human iPSC-derived neurons is essential.
- Hands-on experience differentiating human iPSCs into neuronal cell types and supporting neuronal maturation is strongly preferred.
- Candidates should have experience working routinely with iPSC-derived neuronal cultures, rather than solely non-neuronal iPSC-derived cell types.
- Experience in molecular and cellular laboratory techniques including immunofluorescence/immunocytochemistry, Western blotting, ELISA and other protein-based assays, RNA/DNA extraction, qPCR/RT-qPCR and cell viability assays.
- Ability to work collaboratively within multidisciplinary drug-discovery teams to deliver key data packages.
- Excellent analytical and problem-solving abilities, with strong interpersonal and organisational skills.
- Comfortable working in an early-stage environment and dealing with ambiguity and uncertainty.
- Experience in laboratory health and safety management would be desirable.
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