Sheffield Teaching Hospitals NHS Foundation Trust
BRC MND Project Manager
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NIHR Sheffield BRC - Research Capacity Development Manager
The NIHR Sheffield BRC is a research partnership between Sheffield Teaching Hospitals NHS Foundation Trust and the University of Sheffield, dedicated to improving the treatment and care of people living with debilitating conditions. Research within the BRC focusses on chronic neurological disorders, cardiovascular disorders, and patients with compromised immunity, chronic inflammatory diseases and emerging infections.
The BRC drives research innovation into tangible benefits for patients and the wider society, whilst enhancing the position of the UK as the preferred partner for experimental medicine collaborations. Clinical research projects take place in conjunction with partners within STHFT and will be supported by the NIHR Sheffield Clinical Research Facility.
EXPERTS-ALS
EXPERTS-ALS is a ground-breaking project that provides a platform to test drugs rapidly for their potential to slow the progression of Amyotrophic Lateral Sclerosis (ALS, the commonest form of Motor Neuron Disease (MND)) in people living with ALS. This is done at a pace and scale not previously possible.
Although EXPERTS-ALS cannot prove that a drug does or does not have long-term benefit in MND, it will quickly identify the most promising candidate drugs to go forward into the larger clinical trials needed to test this. This is an £8m investment in MND research by the National Institute for Health & Care Research (NIHR) through the Department of Health and Social Care (DHSC).
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Role Overview
The post holder will provide key project management for the EXPERTS-ALS Programme with a specific focus on research capacity development (WS3) and the pipelines of investigational medicinal products prioritized for use in the platform (WS1).
Key Responsibilities
- Develop the next generation of researchers as a fundamental part of research capacity development in EXPERTS-ALS.
- Support early career researchers (ECRs) to ensure those working on EXPERTS-ALS have access to opportunities beyond their day-to-day research.
- Work with investigators and Clinical Trials Units (CTRUs) to support the pipeline of IMPs entering the platform.
- Support the delivery of a continuous pipeline of drugs for the platform trial using the best available evidence from pre-clinical models and a wide range of data resources, including genomics, AI drug discovery programs and evidence from other neurodegenerative diseases.
- Select the most appropriate compounds for prioritisation in EXPERTS-ALS, based on disease relevance, safety profile and central nervous system penetration.
- Feed data from ECR projects delivered WS3 in response to drugs back to preclinical modelling in WS1 to identify new, or refine existing, pathways of disease relevance, and ultimately those which best predict a positive outcome in Phase III trials.
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Working for Us
You will be working for an organisation which values and respects all of its staff and the community it serves. The Trust is a leader in the NHS and research sectors and provides excellent benefits for its employees. This includes commitments to professional development but also many policies to support employees in balancing their personal and professional lives.
Contract Details
This vacancy is advertised on a fixed term contract basis for a period until 30/09/2028 due to the post being externally funded. The fixed term contract status of the post holder will be reviewed in accordance with the Trust's legal obligations regarding fixed term contracts taking into consideration the ongoing source of the external funding and the requirement for the post to be maintained.
Please note all existing NHS staff will only be considered on a secondment basis. This must first be agreed with your current line manager.
Contact Information
For further details / informal visits contact:
- Name: Luke Barron
- Job title: BRC Operations Manager
- Email address: luke.barron@nhs.net
- Telephone number: 0114 2265924
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