DecenTrialz

Continuation Of A Study To Investigate The Effect Of Thoracocentesis On Neural Respiratory Drive In Pleural Effusion COSINE

London

Posted 26 days ago

How your CV stacks up

1Upload CV

2Analyse CV

3Improve CV

Upload your CV to see how well it fits this job role

Drag and drop your CV

or browse files

Supported files: PDF, DOC, DOCX

Actively Recruiting

Age: 18 Years +

All Genders

ID: 05945043

Continuation of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion COSINE

Led by: Guy's and St Thomas' NHS Foundation Trust

Updated on: 2026-06-04

124 Participants Needed

1 Research Sites

Total Duration

On this page

AI-Summary
Brief Title
Who Can Participate
AI-Screening
Your Study Journey
Trial Site Locations
Research Team
How is the study designed?
Similar Trials
Frequently Asked Questions
Research Publications

AI-Summary

What This Trial Is About

Researchers are investigating the relationship between pleural effusions and breathlessness in adults with unilateral pleural effusions who need fluid removal to manage their symptoms. This observational study will enroll 124 adults over an 18-month period to better understand how removing pleural fluid affects the electrical activity of breathing muscles and patient breathlessness. Participants will undergo measurements including surface parasternal and diaphragm electromyograms (EMG) and parasternal muscle ultrasounds. These assessments will be done before, immediately after, and at 1 and 7 days following pleural fluid removal, which may be done via thoracocentesis, chest drain insertion, or indwelling pleural catheter (IPC). Breathlessness will be measured using the VAS dyspnoea score and Dyspnoea-12 questionnaire. During the study, patients will be evaluated at baseline, immediately post-procedure, and at 1 and 7 days after fluid removal. Researchers will collect data on neural respiratory drive, breathlessness, exercise capacity, and pleural effusion characteristics using thoracic ultrasound. The study will also assess how acceptable it is to include surface parasternal EMG as part of routine clinical practice. Participants will be monitored for up to 7 days post-procedure.

CONDITIONS

Brief Title

Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion

Who Can Participate

Age: 18 Years +

All Genders

Eligibility Criteria

You may qualify if you...

Age 18 years or above
Have a unilateral pleural effusion
Require pleural fluid removal by thoracocentesis, chest drain insertion, or have an indwelling pleural catheter in place

Reasons to use Rodeo

I’m in my final year doing Economics and I don’t know whether to apply for grad schemes now or do a masters first. What do you think?

Honest answer — it depends on where you want to end up. A lot of top grad schemes (Big 4, civil service, banking) don’t need a masters. Let’s look at the ones you’d be competitive for now, and we can decide if a masters actually adds anything.

Also worth knowing: most autumn 2026 applications are open now. Timing matters more than you think.

Start with a chat, not a search bar

Grad scheme, placement, apprenticeship? Not sure what you want yet — that's fine. Your agent talks it through with you and turns "I have no idea" into a shortlist.

It searches the market for you

Every day your agent scans the market matching roles against what actually matters to you, not just keywords on a CV.

Only hits

No noise. No "maybe this fits." Just roles with a clear explanation of why they're right — and where to focus when applying.

You will not qualify if you...

Unable to give informed consent
Have any contraindications to the planned pleural procedure
Have haemodynamic or clinical instability preventing safe pre-procedural measurements
Unable to identify landmarks for surface EMG electrode placement
Have a history of diaphragmatic paralysis (for the diaphragm sub-study only)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

First name *
Last name *
Email Address *
Phone Number *
+1
Gender *
ZIP Code *
I agree to receive SMS messages from DecenTrialz regarding trial matching, appointment updates, participant updates, and related information. Message frequency varies. Message & data rates may apply. Reply STOP to cancel or HELP for assistance. I also agree to the Terms of Service and Privacy Policy.*

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 screening and enrollment visit (in-person)

Monitoring

Duration - 7 days

Participants undergo pleural fluid removal and have measurements taken before, immediately after, and up to 7 days following the procedure to assess breathlessness, breathing muscle activity, and muscle thickness using EMG and ultrasound.

4 visits: pre-procedure, immediately post-procedure, Day 1, and Day 7 (in-person)

Trial Site Locations

Total: 1 location

1. Guy's & St Thomas' NHS Foundation Trust

London, London, United Kingdom, SE1 9RT

Actively Recruiting

Loading map...

Research Team

Junyi Zhang, MBBChir

Gillian Radcliffe

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.

Already have an account? Log in here

Research Publications

The modern diagnosis and management of pleural effusions.

Get help with your application

Your very own career expert that helps elevate your application to the next level.

Get help applying for this job

Rahul Bhatnagar, Nick Maskell

https://pubmed.ncbi.nlm.nih.gov/26350935

The incidence of pleural effusion in a well-defined region. Epidemiologic study in central Bohemia.

M Marel, M Zrůstová, B Stasný...

https://pubmed.ncbi.nlm.nih.gov/8222812

Physiology of breathlessness associated with pleural effusions.

Rajesh Thomas, Susan Jenkins, Peter R Eastwood...

https://pubmed.ncbi.nlm.nih.gov/25978627

Mechanism of relief of dyspnea after thoracocentesis in patients with large pleural effusions.

M Estenne, J C Yernault, A De Troyer

https://pubmed.ncbi.nlm.nih.gov/6837605

Assessment of patient-reported outcome measures in pleural interventions.

Ioannis Psallidas, Ahmed Yousuf, Ambika Talwar...

https://pubmed.ncbi.nlm.nih.gov/28883922

The Pleural Effusion And Symptom Evaluation (PLEASE) study of breathlessness in patients with a symptomatic pleural effusion.

Sanjeevan Muruganandan, Maree Azzopardi, Rajesh Thomas...

https://pubmed.ncbi.nlm.nih.gov/32079642

Dyspnoea: underlying mechanisms and treatment.

T Nishino

https://pubmed.ncbi.nlm.nih.gov/21378105

The relationship between pleural pressures and changes in pulmonary function after therapeutic thoracentesis.

R W Light, D W Stansbury, S E Brown

https://pubmed.ncbi.nlm.nih.gov/3963629

Ultrasound Evaluation of Hemidiaphragm Function Following Thoracentesis: A Study on Mechanisms of Dyspnea Related to Pleural Effusion.

Søren H Skaarup, Sara Lonni, Federico Quadri...

https://pubmed.ncbi.nlm.nih.gov/31651544

Ipsilateral and contralateral hemidiaphragm dynamics in symptomatic pleural effusion: The 2nd PLeural Effusion And Symptom Evaluation (PLEASE-2) Study.

Deirdre B Fitzgerald, Sanjeevan Muruganandan, Carolyn J Peddle-McIntyre...

https://pubmed.ncbi.nlm.nih.gov/35672271

“It took my CV and asked me questions relevant to understanding what kind of jobs to suggest for me. Suggestions were almost perfect. Jobs were exactly what I’ve been looking for.”

Jessica, London