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Correlation Of Fractional Flow Reserve Computed Tomography FFR CT Findings With Invasive FFR In Coronary Artery Disease In A Multi-Ethnic Cohort - Retrospective Study
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ID06790836
Correlation of Fractional Flow Reserve Computed Tomography FFR CT Findings With Invasive FFR in Coronary Artery Disease in a Multi-ethnic Cohort - Retrospective Study
Led by Sandwell & West Birmingham Hospitals NHS Trust
Updated on 2026-05-07
500
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
- AI-Summary
- Brief Title
- Who Can Participate
- AI-Screening
- Your Study Journey
- Trial Site Locations
- Research Team
- How is the study designed?
- Similar Trials
- Frequently Asked Questions
- Sponsors
AI-Summary
What This Trial Is About
Researchers are investigating the relationship between Fractional Flow Reserve Computed Tomography FFR CT and invasive Fractional Flow Reserve FFR in patients with suspected stable coronary artery disease CAD. This retrospective study analyzes data from around 500 patients who underwent CT Coronary Angiogram CTCA, FFR CT, and invasive FFR at Sandwell and West Birmingham NHS Trust between 2019 and 2023. The study aims to evaluate the diagnostic accuracy of FFR CT compared to invasive FFR across different ethnic groups, potentially supporting wider use of this non-invasive test to reduce invasive procedures, related risks, and healthcare costs. The study involves reviewing existing clinical and imaging data, including high-quality CTCA images and corresponding FFR CT and invasive FFR measurements. Researchers will collect demographic information such as age, gender, body mass index, cardiovascular risk factors, and vessel characteristics. Statistical analysis will compare diagnostic metrics like sensitivity, specificity, positive and negative predictive values, and overall accuracy of FFR CT against invasive FFR, providing detailed insights into their correlation and discrepancies. Participants are not actively recruited since this is a retrospective analysis using anonymized data from patients who have already undergone these diagnostic tests. The study team will ensure patient confidentiality by coding and securely storing data on NHS Trust computers. The main outcome measured is the correlation between FFR CT and invasive FFR over a six-month period. Secondary measures include reviewing any additional tests done after FFR CT. The findings aim to improve understanding of non-invasive coronary diagnostics and their practical use in patient care.
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CONDITIONS
Brief Title
Correlation of FFR CT With Invasive FFR in Multi-ethnic Cohort- a Retrospective Study
Who Can Participate
Age: 18 Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Stable patients with suspected coronary artery disease
- Patients who have undergone CT Coronary Angiogram (CTCA), FFR CT, and invasive FFR
- High-quality CTCA images with clear visualization of coronary arteries and minimal artifacts
You will not qualify if you...
- Younger than 18 years of age
- Did not undergo FFR CT
- Inadequate quality or degraded CTCA images
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration: 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
- 1 visit (in-person)
Diagnostic Evaluation
Duration: Retrospective analysis of data from January 2019 to December 2023
Participants' existing clinical and imaging data including CT Coronary Angiogram (CTCA), FFR CT, and invasive FFR are analyzed to assess diagnostic accuracy and correlation.
- No visits required; analysis is performed on existing data
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Long-term Monitoring
Duration: Up to 6 months
Participants' diagnostic data are observed for correlations and downstream testing outcomes to provide insights into diagnostic performance and patient care.
- No visits required; follow-up is based on existing health records
Trial Site Locations
Total: 1 location
- Sandwell and West Birmingham NHS Trust
- Birmingham, West Midlands, United Kingdom, B71 4HJ
Research Team
- Vinoda Sharma, FRCP FESC FRCPE
How is the study designed?
- Study Type: OBSERVATIONAL
- Masking: N/A
- Allocation: N/A
- Model: N/A
- Primary Purpose: N/A
- Number of Arms: 0
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Frequently Asked Questions
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Sponsors
- S Sandwell & West Birmingham Hospitals NHS Trust
- A Aston University
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