Director, Project Toxicologist – Immune Oncology (IO) Safety Science

Location: Cambridge, UK (Hybrid, required 60% presence in the office)
Salary: Competitive

At AstraZeneca, our bold ambition is nothing less than to eliminate cancer as a cause of death. Our pioneering pipeline of oncology medicines reflects this mission, and our Immune Oncology (IO) Safety team plays a critical role in accelerating transformative therapies to patients.

We are seeking a highly motivated, innovative, and passionate Director, Project Toxicologist, to join our IO Safety group. This role focuses on novel immunotherapeutic, including immune cell engagers. Candidates with a strong Immunology and toxicology background, preferably in Oncology, are encouraged to apply.

You will partner with cross-functional teams across Oncology R&D, bridging discovery and regulatory toxicology, Immunotoxicology, driving innovative safety strategies, and accelerating drug development. Your expertise will inform candidate selection, guide regulatory strategy, and help define the future of oncology safety science.

What You’ll Do

• As a core member of multi-disciplinary drug development teams, you will deliver globally acceptable toxicological packages to predict, assess and mitigate target and modality related safety risks to support data-driven decisions across discovery and development programs.
• You will develop and implement innovative solutions to combine regulatory toxicology with ground breaking science and technologies to progress novel drug candidates to the clinic and through development to the market, in line with business needs.
• Influence project strategy and decision making, communicate clear positions on integrated risk assessments in various formats including informing internal decision-making governance bodies and interacting with external health authorities.
• Deliver quality non-clinical summaries and contribute to regulatory submissions for IO projects.
• Maintain and expand expertise in regulatory standards, preclinical safety, and modality-specific safety science, staying ahead of industry trends.
• Drive Oncology Safety science through internal and external collaborations, publications, and scientific leadership.
• Additional responsibilities include providing experienced non-clinical evaluation of in-licensing and out-licensing opportunities, mentorship and guidance to emerging toxicologists with respect to regulatory environment and supporting their career growth and development.