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Immunocore

Executive Director, Clinical Development Physician (Autoimmune)

Oxford
Posted about 21 hours ago
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Location of role: Gaithersburg, MD, Radnor, PA, Oxford, UK

Department: Clinical Development

Key Responsibilities

The Executive Director, Early-Stage Clinical Development, Autoimmune will:

  • Drive assigned autoimmune programs from pre-clinical stages to proof of concept.
  • Contribute to the development of infrastructure within Immunocore’s Clinical Sciences department by leading designated projects and workstreams.
  • As the assets develop into the clinic, build a small team.
  • Spearhead Clinical Development strategic planning and be responsible for the design and medical oversight of assigned clinical studies. This includes protocol development, medical monitoring, medical data review, results interpretation, reporting, and regulatory submissions.
  • Lead innovation in trial design, including the development of biomarker strategies.
  • Think strategically at both the program and enterprise levels, with the ability to analyze data, troubleshoot programs, and develop risk mitigation plans.
  • Provide strong strategic leadership, advisory skills, and close collaboration with cross-functional teams whilst providing oversight, guidance, and mentorship to junior physicians working in early-stage clinical trials.

The Executive Director will interact with all levels of management, peers, and leaders from academic centers involved in key collaborations, as well as external stakeholders in the medical and scientific community and global regulatory authorities.

Experience and Knowledge

The ideal candidate is an MD or MD/PhD scientist with a clinical perspective, a track record of exceptional achievements in autoimmune therapy development and expertise in multiple disease areas including dermatology and/or type 1 diabetes. They have:

  • Thorough understanding of the early drug development process including experience contributing to key clinical documents (e.g., protocols, ICF, IB, DSUR, CRF), reviewing and interpreting clinical data.
  • A strategic and critical mindset with strong problem-solving and analytical skills, as well as a proven ability in designing innovative clinical trials that have supported successful regulatory filings.
  • Expertise in presenting key headline data with professional authority, anticipating and addressing questions/concerns from senior leadership in a governance setting.
  • Established links with the medical community globally and locally, with proven ability to develop close working relationships with opinion leaders.
  • Working knowledge of GCP, ICH, GDP and relevant CFRs is required; familiarity with MHRA, EMA, and CHMP regulations and guidelines and other international regulatory requirements is a plus.
  • Solid working knowledge of Microsoft applications such as Excel, Access, Word, and Outlook.

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Leadership and Stakeholder Management

  • Demonstrated ability to build mutually respectful relationships with colleagues, troubleshoot challenges and provide direction, guidance, and support to the team to achieve near-term goals.
  • Proven team leadership experience, and a view on talent within the industry; ideally having appointed scientists and domain experts into their team.
  • Ability to facilitate discussions and collaboration among groups with diverse technical expertise, gain alignment and progress decisions on moderate to high complexity issues.
  • Capable of providing clear direction and holding teams accountable to deliver timely execution of objectives. Motivate and energize cross functional team members to achieve aggressive goals.
  • Strong oral and written communication skills, professional presence, and demonstrated ability to engage effectively with stakeholders at all levels including senior leaders.
  • Foundational people management skills with the ability to oversee and manage the activities of junior physicians and clinical scientists, mentor colleagues, and bring the Immunocore vision and strategy to life for others at all levels.

Education And Qualifications

  • The ideal candidate is an MD or MD/PhD, ideally with relevant training in treating immune mediated diseases.
  • 5-8 years of relevant experience in clinical drug development OR 2-5 years of relevant clinical development experience with 5-10 years in clinical practice in a related field.
  • At least two years of experience as a medical monitor in a biopharmaceutical company, and/or CRO.
  • Strong understanding of pharmacokinetics, biomarkers, statistical principles, and regulatory requirements and demonstrated experience integrating these disciplines in the context of drug development.
  • A broad understanding of autoimmune disease area; experience in dermatology and / or type 1 diabetes is highly desirable.

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About the Company

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

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Skills

Clinical Development Planning
Medical Monitoring
Protocol Development
Autoimmune Disease Expertise
Regulatory Submissions
Trial Design
Biomarker Strategy
GCP
ICH
GDP
Stakeholder Management
People Management
Medical Data Review
Cross-functional Leadership
KOL Relationship Management
Pharmacokinetics

Location

Oxford, England, United Kingdom

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