The post holder will be responsible for undertaking laboratory-based work to improve methods and analytical algorithms to detect and characterize polio and novel oral polio viruses in clinical samples by Long read sequencing using Nanopore technology and short read sequencing using illumina systems. These include performing molecular assays including RT-PCR, RT-qPCR and next generation sequencing analysis of viral nucleic acid preparations from stool followed by bioinformatic analysis and single nucleotide variant calling from each sample.

The post holder will also be responsible for undertaking laboratory-based work related to the use and further development and validation of viral Internal process control (IPCs) material. The Post holder will perform spiking experiments and test these IPCs for fit for purpose testing. The post holder will also contribute towards the long-term objective of the group to develop strategies for multi-pathogen detection in wastewater samples to help the early detection of human pathogens and contribute to pandemic preparedness.

There is a requirement for excellent coordination and communication with teams in the R&D function as well as across Standards Lifecycle and Control Testing, as necessary to support analytical requirements for these statutory functions.

Person specification

Key responsibilities:

• Be accountable to the line manager, coordinating with other teams and colleagues across S&R functions as required, to effectively manage the work programs on a day-to-day basis.
• Perform analytical assays for e.g., nucleic acid extraction from clinical and environmental samples, concertation of environmental samples, Conventional PCR, Real-time PCR detecting poliovirus and other enteric pathogens from wastewater surveillance activities.
• Running high throughput sequencing on nanopore and Illumina systems. Bioinformatic analysis of the data produced from both long read and short read sequencing.
• Participate in international collaboration programs for the development of standardized methods and reference standards for laboratory assays.
• Analyze complex data arising from work above and contribute to the preparation of scientific reports and papers using a variety of computer software packages for publication and presentation to other scientists.

Who are we looking for?

Our successful candidate will have the following:

• A BSc in a relevant field (MSc desirable) or equivalent experience with evidence of R&D.
• Experience of implementing, developing and optimising laboratory procedures and conducting research experiments with accurate record keeping and reporting on findings.
• Experience of working independently as well as within a team, with good time-management and great attention to detail.
• Sound knowledge of biosafety regulations to work with human and animal infectious samples (CL2/3).
• Skills in molecular and cell-based assays applicable to viral diseases and virus characterisation including nucleic acid extraction, RT-PCR and sequencing.
• Experience with statistical analysis and interpreting results derived from large complex data sets, generating clear reports and scientific manuscripts.

Behaviours

We'll assess you against these behaviours during the selection process:

• Working Together

Technical skills

We'll assess you against these technical skills during the selection process:

• Sound knowledge of biosafety regulations to work with human and animal infectious samples (HSB 2/3) and ability to work in the demanding environment of a high containment facility following protocols and adhering to safe working practices.
• Skilled in molecular assays applicable to viral diseases including nucleic acid extraction and sequencing methods.
• Highly skilled in cell culture-based assays including virus titration.

Benefits

Alongside your salary of £37,456, Medicines and Healthcare Products Regulatory Agency contributes £10,851 towards you being a member of the Civil Service Defined Benefit Pension scheme. Find out what benefits a Civil Service Pension provides (opens in a new window).

• Annual Leave: 25 days annual leave on entry, rising by one day for each completed year of service to a maximum of 30 days and pro-rata for part-time staff. PLUS 8 bank holidays
• Privilege Leave: 1 day
• Hours of Work: 37 hours (net) per week for full time staff in all geographical locations, including London and pro rata for part-time staff
• Occupational Sick Pay (OSP): One month full pay/one month half pay on entry, rising by one month for each completed year of service to a maximum of six months full pay and six months half pay after five years’ service.
• Mobility: Mobility clause in contracts allowing staff to be mobile across the Civil Service
• Civil Service Pension Scheme. Please see the link for further information http://www.civilservicepensionscheme.org.uk/ For enquiries relating to the Civil Service Pension Schemes please contact MyCSP's Pension Service Centre directly on 0300 123 6666
• Flexible working to ensure staff maintain a healthy work-life balance
• Interest free season ticket loan or bike loan
• Employee Assistance Services and access to the Civil Service Benevolent Fund
• Eligibility to join Motoring, Boundless by CSMA
• Variety of staff and Civil Service clubs
• On-going learning and development

Artificial intelligence

Artificial intelligence can be a useful tool to support your application, however, all examples and statements provided must be truthful, factually accurate and taken directly from your own experience. Where plagiarism has been identified (presenting the ideas and experiences of others, or generated by artificial intelligence, as your own) applications may be withdrawn and internal candidates may be subject to disciplinary action. Please see our candidate guidance (opens in a new window) for more information on appropriate and inappropriate use.

Selection process details

This vacancy is using Success Profiles (opens in a new window), and will assess your Behaviours, Strengths, Experience and Technical skills.

We use the Civil Service Success Profiles to assess our candidates, find out more here.

• Online application form, including a statement of suitability, of no more than 500 words demonstrating how you meet the person specification. Please ensure all application questions are completed in full; your application may not be considered if any responses are left blank. Our applications are CV blind, and our Hiring Managers will not be able to access your CV when reviewing your application. Please ensure not to include any personal identifying information on your supporting information.
• Interview, which can include questions based on the Behaviour, Experience, Technical and Strengths Success Profiles.

Applicants are assessed on whether they meet any mandatory requirements as well as the necessary skills and experience for the role. Applications are scored based on the statement of suitability provided. You can view the criteria for this role in the job description.

If you require any disability related adjustments