Barrington James
In Vivo Research Scientist
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We are supporting a growing research organization seeking an experienced Research Scientist to join their team, working across preclinical and early clinical gene therapy programs. The ideal candidate will have experience with technically challenging in vivo procedures, with ocular/retinal experience particularly desirable. Strong brain/CNS/neuroscience experience will also be considered.
You will play a key role in establishing, developing, and executing in vivo studies, supporting programs from early preclinical research through into early clinical development.
With multiple programs currently underway and further projects entering the pipeline, this is an opportunity to join a growing team and have genuine input into the development and progression of gene therapy programs.
Key Responsibilities
- Design, establish, and execute in vivo gene therapy studies in mice.
- Take studies from initial set-up through to execution, data interpretation, and reporting.
- Develop and optimize in vivo potency and safety assays supporting gene therapy programs.
- Work with ocular/retinal, brain, or CNS models, particularly technically challenging or specialized procedures.
- Support the development and evaluation of AAV-based gene therapies and associated therapeutic readouts.
- Troubleshoot studies and develop new approaches, techniques, and experimental workflows.
- Analyze and interpret preclinical data to support program progression towards the clinic.
- Produce high-quality study reports, SOPs, experimental protocols, and work instructions.
- Contribute to the establishment and implementation of new in vivo models, assays, and laboratory processes.
- Work collaboratively across R&D, quality, regulatory, and compliance functions.
- Support programs across both preclinical research and early clinical development.
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What We're Looking For
- Strong, hands-on in vivo experience using mice.
- Current or previous Home Office Personal Licence (PIL A/C).
- Experience performing technically challenging or specialized in vivo procedures.
- Proven experience within gene therapy, ideally AAV-based gene therapy.
- Strong preclinical research experience.
- Experience setting up, establishing, or taking ownership of new in vivo studies.
- Experience writing study reports, SOPs, protocols, and scientific documentation.
- Strong experimental design, data interpretation, and troubleshooting skills.
- Ocular/retinal in vivo experience, alternatively, strong brain/CNS/neuroscience experience.
Desirable
- Experience with AAV vector systems and gene therapy potency/efficacy readouts.
- Understanding of how preclinical data supports progression into clinical programs.
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