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Inflammatory And Neural Correlates Of Chemotherapy-Induced Cognitive Impairment A Pilot Study
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Age: 18 Years +
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ID: 05740787
Inflammatory and Neural Correlates of Chemotherapy-Induced Cognitive Impairment A Pilot Study
Led by: University of Aberdeen
Updated on: 2026-05-08
Participants Needed: 50
Research Sites: 1
Total Duration: N/A
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- AI-Summary
- Brief Title
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- Your Study Journey
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- Research Team
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AI-Summary
What This Trial Is About
Researchers are investigating the cognitive changes often called chemobrain that affect some breast cancer patients receiving chemotherapy. This condition includes problems with concentration, memory, and thinking speed, which can significantly impact daily life. The study aims to understand how chemotherapy may cause brain inflammation and changes by measuring brain iron levels, cognitive abilities, and inflammation markers in the blood before, during, and after treatment. The study involves 50 breast cancer patients undergoing either neoadjuvant or adjuvant chemotherapy, focusing mainly on common treatments like anthracyclines with or without taxane. Participants will have three visits for brain MRI scans and cognitive testing within two weeks of diagnosis, four weeks after the last chemotherapy cycle, and six months after completing chemotherapy. The scans will include detailed brain imaging sequences to assess brain volume and function, while cognitive tests will measure memory, processing speed, verbal fluency, and fatigue. At each visit, blood samples will be collected to analyze inflammation-related chemicals and iron levels. The research team will compare changes in brain iron, cognitive function, and blood markers over time to better understand chemotherapy's impact on the brain. The main outcome is cognitive performance six months after chemotherapy. This observational study involves no intervention and monitors participants over several months to gather important data on chemobrain.
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CONDITIONS
Brief Title
Chemotherapy Induced Cognitive Impairment
Who Can Participate
Age: 18 Years +
All Genders
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Eligibility Criteria
You may qualify if you...
- Women and men older than 18 years
- Diagnosed with HER2 negative breast cancer
- Receiving EC-Taxane or Taxane-based chemotherapy
- Able to communicate in English
- Willing and able to give informed consent for participation in the study.
You will not qualify if you...
- Physical condition prevents lying still for brain scan duration
- Pre-existing mental condition or disability
- Contraindication to MRI such as having an implantable cardiac device
Research Team
Teresa Morris
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On this page
- AI-Summary
- Brief Title
- Who Can Participate
- AI-Screening
- Your Study Journey
- Trial Site Locations
- Research Team
- How is the study designed?
- Similar Trials
- Frequently Asked Questions
- Sponsors
Sponsors
U
University of Aberdeen
Lead Sponsor
N
NHS Grampian
Collaborating Sponsor
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