Nexus Life Sciences
Method Development Lead
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About the Role
We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.
This role combines technical expertise and team leadership.
Responsibilities
Key duties include:
- Leading method development and validation as a subject matter expert.
- Optimising analytical extraction techniques, chromatography methods, and LC columns.
- Managing and mentoring the Method Development & Validation team.
- Ensuring compliance with GLP, SOPs, and international guidelines.
- Troubleshooting analytical methods and recommending improvements.
- Overseeing cost-effective laboratory operations and consumable spend.
- Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
- Supporting regulatory submissions and resolving regulatory queries.
- Conducting investigations, implementing CAPAs, and driving continuous improvement.
- Preparing, reviewing, and ensuring adherence to GLP SOPs.
- Leading team meetings and staff development sessions.
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Qualifications
- Degree in Biochemistry, Biomedical Science, or related field.
Required Skills
- 4+ years in a GxP laboratory (2+ years in management).
- Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
- Proficiency in method development, optimisation, and validation.
- Strong problem-solving and troubleshooting capabilities.
- Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
- Understanding of regulatory and GLP requirements.
- Strong communication, organisational, and leadership skills.
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Preferred Skills
- Experience with Design of Experiments (DOE) for method optimisation.
- Proficiency in Minitab/statistical software.
- Experience with Empower and Mass Lynx data systems.
- GC experience and familiarity with regulatory inspections.
Pay range and compensation package
- Competitive salary up to £60,000.
- Leadership opportunity in a cutting-edge lab environment.
- Professional development and training opportunities.
- Supportive, collaborative work culture.
- Chance to contribute to innovative bioanalytical projects.
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