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Peri-Operative Measurement Of NT-ProBNP To Predict Outcomes In Patients Undergoing Elective Vascular Surgery
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ID: 04014647
Peri-operative Measurement of NT-proBNP to Predict Outcomes in Patients Undergoing Elective Vascular Surgery
Led by: Norfolk and Norwich University Hospitals NHS Foundation Trust
Updated on: 2026-06-08
200 Participants Needed
1 Research Site
Total Duration: N/A
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AI-Summary
What This Trial Is About
Researchers are evaluating whether measuring N-terminal pro B-type natriuretic peptide NT-proBNP and other heart-related markers can help predict outcomes for patients undergoing elective major vascular surgery. The study aims to identify high-risk patients who may face serious complications like heart attacks or death after surgery. Understanding these risks could help guide treatments to improve patient care and long-term health. This observational study measures NT-proBNP levels before and four days after surgery. It also tracks other markers such as troponin I, galectin-3, CRP, and creatinine during the same peri-operative period. Patients are grouped based on whether they experience negative events post-surgery, including cardiac events, infections, kidney issues, or extended hospital stays. Participants will have blood tests at specified times around surgery and be monitored for various clinical events within 31 days after surgery. The study collects data on hospital stay length, use of antibiotics, inotropic support, and kidney alerts. Researchers aim to use these measurements to better predict patient outcomes and potentially guide future interventions for improved recovery and survival.
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CONDITIONS
Brief Title
Measurement Of NT-proBNP to Predict Outcomes in Surgery
Who Can Participate
Age: 18 Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Patients who are equal to or over 18 years old
- Patients scheduled to undergo elective surgery for infrainguinal arterial reconstruction
- Patients scheduled to undergo elective surgery for aortic aneurysm
- Patients scheduled to undergo elective surgery for aorto-bifemoral bypass or aortic endarterectomy
- Patients scheduled to undergo elective surgery for femoro-popliteal bypass
- Patients scheduled to undergo elective surgery for femoro-distal bypass
- Patients scheduled to undergo elective surgery for femoral endarterectomy
- Patients scheduled to undergo elective surgery for femoro-femoral crossover
- Patients scheduled to undergo elective surgery for axillo-femoral bypass
- Patients scheduled to undergo elective carotid surgery
- Patients having either general or regional anaesthesia for their surgery
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You will not qualify if you...
- Patients undergoing emergency surgery
- Patients unable or unwilling to give informed consent
- Patients with unstable coronary syndromes including recent myocardial infarction or severe angina
- Patients with decompensated heart failure with new or worsening symptoms
- Patients with chronic atrial fibrillation
Research Team
- E: Emma Miler, MSc BSc Hons
- A: Allison Chipchase, Dr
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Sponsors
N: Norfolk and Norwich University Hospitals NHS Foundation Trust
Lead Sponsor: Norfolk and Norwich University Hospitals NHS Foundation Trust
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