Universitätsklinikum Münster
PhD Student (gn*) Life Sciences, Biotechnology or Biomedicine
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Job Title
Fixed-term for 3 years | Part-time at 65% | Salary according to TV-L E13 | Department of Medicine D
About Us
We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise in the Department of Medicine D – ideally with you on board!
About the Research
Chronic kidney diseases are among the ten most common causes of death worldwide. Highly specialized podocytes play a central role in the kidney’s filtration function. Many nephrotic syndromes are caused by genetic variants in podocyte-specific proteins. One of these is Crumbs2, an apical polarity and cell-contact protein whose loss leads to damage of the kidney filtration barrier and can ultimately result in chronic kidney disease.
This project investigates the crosstalk between apical cell contacts – depending on Crumbs2 – and focal adhesions in podocytes. Genetically modified mouse models and cell lines as well as high-resolution microscopy, molecular biology methods, transcriptomic analyses, and proteomic analyses will be used to address this research question.
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Responsibilities
- Working with genetically modified mouse lines
- Processing and analysis of transcriptomic and phosphoproteomic samples from murine tissue and cell cultures
- Application of high-resolution microscopy techniques
- Complex genetic modification of cell lines
- Molecular and cell biological analyses to investigate podocytes
Requirements
- Completed university degree (M.Sc.) in Life Sciences, Biotechnology, Biochemistry or Biomedicine
- Very good knowledge of molecular and cell biology
- Practical experience with cell culture
- Willingness to conduct animal-based research as part of the research project
- Good knowledge of confocal microscopy
- Very good command of English
- Independent, structured and goal-oriented approach to work as well as reliability and team orientation
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What We Offer
- Salary according to TV-L E13, Extra annual payment, and company pension plan (VBL)
- 30 days of vacation per year, plus two additional days off on Christmas Eve and New Year's Eve
- A wide range of training and professional development opportunities
- A well-equipped laboratory and close individual supervision
- Integration into a graduate school
- A respectful and appreciative work environment within an interdisciplinary team of biologists and physicians
- Support and advisory services for health and work-life balance
- Additional benefits such as sports programs, job ticket, jobrad, company events, cafeteria, and emergency childcare
Contact
For inquiries, please contact: Dr. Annika Möller-Kerutt, Project Leader, T +49 251 83-44967
How to Apply
Apply now via our career portal.
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