University of Edinburgh
Post-Doctoral Research Associate
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UE07: £41,064 - £48,822 per annum
CMVM / Institute of Genetics and Cancer
Full-time: 35 hours a week
Fixed-term: 30 months
The Opportunity
An exciting postdoctoral position is available to research the role of epigenetic marks in gene regulation.
We are looking for a self-motivated, enthusiastic postdoctoral research associate to join the laboratory of Dr Duncan Sproul at the University of Edinburgh’s Institute of Genetics and Cancer to understand the role of DNA methylation in gene regulation. This project is a close collaboration with 3 other groups based at the Universities of Edinburgh and Exeter.
We have recently characterised mutations that prevent the DNA methyltransferase DNMT3B from being recruited to actively transcribed gene bodies (Taglini et al. 2024, EMBO Reports 25:1130, DOI: 10.1038/s44319-024-00061-5). Our new project will use this knowledge combined with recently developed synthetic approaches as an entry point to probe the non-canonical regulation of transcription by DNA methylation within gene bodies and its functional impact on cellular phenotypes.
The successful candidate will work with the Sproul and collaborating laboratories as part of a successful multidisciplinary research team. This project will have a particular emphasis on the use of sequencing based functional genomics assays (eg TT-seq, CUT&RUN, Nanopore sequencing) in human embryonic stem cell models and work with synthetic landing-pad based approaches.
Candidates who have been awarded, or are soon to be awarded, a PhD in a relevant discipline and have experience with a broad range of molecular biology, cellular biology, biochemistry and/or computational data analysis approaches are invited to apply. Applicants must possess the ability to think independently while working within an interdisciplinary research team to drive research projects towards publication. Candidates with a strong track record in epigenomics, gene regulation and/or the use of human stem cells models are particularly welcome.
The post is full-time (35 hours per week) and funding is available from 1st January 2027 for 2.5 years pending review after 6 months.
Further details of work from the Sproul research group is available at: https://institute-genetics-cancer.ed.ac.uk/research/research-groups-a-z/sproul-group
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Click to view a copy of the full Job Description https://uoe.sharepoint.com/:w:/s/jobdescriptionlibrary/IQBvPh3u8-7cSISxNpaVUx-VARX0Uzi8mC9LdMwrd5iiKwI
How to apply
Please include the following documents in your application:
- CV
- Cover letter
- Details of 2 referees
The cover letter and CV should clearly describe how you meet each of the selection criteria listed in the job description.
As a valued member of our team, you can expect:
- A competitive salary.
- An exciting, positive, creative, challenging and rewarding place to work.
- To be part of a diverse and vibrant international community.
- Comprehensive Staff Benefits, including generous annual leave entitlement, a defined benefits pension scheme, a wide range of staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our staff benefits page (opens in a new tab) and use our reward calculator to discover the value of your pay and benefits.
Championing equality, diversity, and inclusion
The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter, and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.
Prior to any employment commencing with the University, you will be required to evidence your right to work in the UK. Further information is available on our right to work webpages (opens new browser tab)
The University may be able to sponsor the employment of international workers in this role. This will depend on a number of factors specific to the successful applicant.
Key dates to note
The deadline for applications is 14th October 2026.
Unless stated otherwise the closing time for applications is 11:59pm UK time. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browser's local time zone.
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We aim to hold initial interviews starting the week beginning [2nd November 2026]. During the process we also hope that the successful applicant will have the chance to visit the Sproul lab at the Institute of Genetics and Cancer.
The Institute of Genetics and Cancer
The Institute of Genetics and Cancer is an international research institute that is part of the University of Edinburgh and is located on the Western General Hospital campus. It hosts 70 research groups and over 500 scientists, support staff, fellows, PhD students and visiting scientists. The institute has a strong culture of collaboration, interaction and mentoring diverse careers.
As a world-leading research-intensive University, we are here to address tomorrow’s greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.
The School of Genetics and Cancer is one of the six Schools that make up the College of Medicine and Veterinary Medicine (CMVM). The School is home to the Institute of Genetics and Cancer (IGC) whose goals are to carry out excellent genetic, genomic, cellular and clinical science, so that we contribute significantly to the understanding of human development, physiology and disease, and apply this knowledge for the benefit of patients and society. The IGC is one of the College’s five world-leading research institutes. The teams in the six CMVM Schools work together to build outstanding discovery and translational research programmes designed to answer the major challenges facing humanity, animal and planetary health, now and in the future. The College’s undergraduate and postgraduate teaching is delivered through Edinburgh Medical School and the Royal (Dick) School of Medical Studies with contributions from all six schools.
To find out more visit: School of Genetics and Cancer webpage https://medicine-vet-medicine.ed.ac.uk/school-of-genetics-and-cancer
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