Instruct-ERIC
Postdoctoral Research Scientist in Correlative Imaging of HIV-1 Transcription and Latency in CD4⁺ T Cells
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University of Oxford, The Division of Structural Biology, United Kingdom
Application deadline: 01 Sep 2026
We are seeking to appoint a Postdoctoral Research Scientist to manage and carry out the Correlative Imaging of HIV-1 Transcription and Latency in CD4⁺ T Cells project day-to-day. The goal of this project is to establish and apply innovative imaging methods and tools for the structural characterization of HIV persistence.
Project Aims
- Aim 1: Establish a dual-reporter strategy in CEM cells to simultaneously label proviral DNA and nascent viral RNA, enabling discrimination of transcriptionally active and silent proviruses and mapping of their perspective nuclear environments through live-cell imaging and correlative cryo–electron tomography.
- Aim 2: Extend these approaches to physiologically relevant primary CD4⁺ T cells, defining and classifying distinct nuclear structural features associated with HIV-1 latency and active transcription.
Responsibilities
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- Manage the project day-to-day, including both design and action of strategies in molecular biology, protein biochemistry, cell modification (CRISPR), and cellular imaging.
- Perform structural studies using SPA cryoEM, cryoET, and other appropriate methods.
- Manage your own academic research and administrative activities.
- Use specialist scientific equipment in a laboratory environment.
- Carry out collaborative projects with colleagues in partner organizations and research groups.
- Supervise students.
- Contribute to the overall development of our programme and prepare for the next stages in research.
Requirements
- Hold a PhD/DPhil (or close to completion) in structural and functional studies of virus infections, or other relevant subject.
- Demonstrable decision-making, problem-solving, and planning within a research environment.
- Research experience in molecular biology, protein biochemistry, and cryoEM structure determination.
- Experience in the area of retroviruses and in-situ structural biology including cryoET subtomogram averaging.
- Ability to drive and lead the research project, manage the day-to-day running, and assist junior researchers.
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Application Process
Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.
Contract Details
This position is offered full time on a fixed-term contract until 31 May 2028 and is funded by NIH/NIAID.
Important Dates
- Only applications received before 12 midday on 1 September 2026 will be considered.
- Please quote 186683 on all correspondence.
Application Link
For more information and to apply, please see here.
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