Rosalind Franklin Institute
Postdoctoral Researcher in Quantitative Cell Biology/Biochemistry (10410)
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Rosalind Franklin Institute
The Rosalind Franklin Institute (the Franklin) is a technology institute established by the UK Government as a unique centre committed to advancing tools that are needed to transform healthcare in the future.
The Institute brings together researchers in life and physical sciences, and engineering, to develop a spectrum of tools which we will use to image, interpret and intervene in biological systems. These insights will speed up the discovery of new medicines, help find new diagnostics and contribute to a deeper understanding of human health and disease. Our Science Strategy seeks to focus the Franklin’s research and unite our researchers around our Technology Innovation Challenges and Life Science Challenges. For more information on the Franklin’s Challenges click here.
If you are a creative scientist who would like to work in collaboration between biophysics, structural biology and biochemistry, then join us. Our labs (Pombo-Garcia & Wu) are interested in molecular organisation of cell interfaces in the epithelial tissue and glycobiology. We use super-resolution STED microscopy, CryoET, in combination with biophysics and chemical biology, to uncover how epithelial cells organise in space and time under different physico-chemical environments to drive self-organisation processes, like condensates, that shape mesoscale structures enabling tissue function.
As a Postdoctoral Researcher at the Rosalind Franklin Institute, you will bring scientific knowledge and skills to deliver a specific research project and/or you will bring independent, creative science, or specific skills to a team delivering a project or program. Through this work, you will build scientific independence, develop new science and leadership skills, and establish a growing reputation externally. Your role will be to lead a research project focused on developing tools for quantitative imaging of epithelial cell biology and biophysics. Moreover, you will support and develop novel workflows of bioimaging analysis to quantify advanced imaging data generated by super-resolution STED microscopy, FLIM, FRET and FCS.
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Key Responsibilities
- Lead a project on quantitative cell biology of cell interfaces.
- Develop novel tools to visualise biomolecules (lipids, glycans, proteins) in cells to observe the dynamic formation of cell interfaces in epithelia.
- Generate complex data based on super-resolution fluorescence and CryoET and analyse data.
Requirements
- Hold a PhD in cell biology, biophysics or biochemistry.
- Experience in advanced quantitative microscopy analysis.
- Strong organisational and communication skills.
- Demonstrated laboratory experience.
- Experience in formulating research questions and devising strategies to address these questions.
Benefits
We encourage applicants with a broad experimental-analytical interest, as the job holder will contribute both to the development of new methods and their application to investigate the organisation and dynamics of cell interfaces.
In return we offer:
- 25 days holidays plus bank holidays and Christmas holiday shutdown
- Generous pension scheme (employer’s contribution currently up to 18%)
- Group Life Assurance (also known as Group Life Insurance or Death in Service)
- Buying and Selling Annual Leave
- Workplace Nursery Salary Sacrifice Scheme
- Hybrid and flexible working
- Training and development opportunities for staff at all levels
- Bus pass discount scheme and good transport links to Oxford and surrounding areas
- Cycle to Work Scheme
- Access to employee discount platform (Perkbox)
- Occupational Health and wellbeing support including Employee Assistance (24/7 support and counselling)
- Health Cash Plan
- Subsidised canteen and food outlets on campus
- Free on-site parking
- Campus location in beautiful countryside with social and sports clubs open to staff
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How to Apply
To be considered for this role, please upload a CV and cover letter explaining why you think you are the right person for this job. The link to apply is provided on our career website.
- AREA: Scientific
- LOCATION: Harwell Campus, Oxfordshire
- TYPE OF POST: Full-Time (37.5 hours per week)
- PERIOD OF APPOINTMENT: 2 Years Fixed-Term Contract
- SALARY: From £39,500 per annum (depending on skills and experience)
- CLOSING DATE: 27/09/2026
- REF NO: 10410
The Franklin’s underlying aim is to produce the best science for research today, and this means resolutely embracing a diverse team, who have a wide range of experiences, skills and knowledge to push forward on the innovative work our institution delivers. Both our work and our institution are better for it. For further information, view our Equality, Diversity and Inclusion Policy.
We are committed to creating an inclusive environment where every applicant has an equal opportunity to showcase their talents and abilities. This includes making adjustments for candidates with specific needs. Please contact us at recruitment@rfi.ac.uk to discuss your requirements confidentially.
At the Rosalind Franklin Institute we also welcome applications from all around the world!
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