Hudson Shribman
Preclinical In-Vitro Toxicology Scientist
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Preclinical In-Vitro Toxicology Scientist up to c£70k + Bonus + Benefits
Hampshire, Full Time ABJ6761
ONSITE- Hybrid – PERM
An exciting opportunity has arisen for an experienced In-Vitro Regulatory Toxicology Scientist to join a leading scientific research and product development organisation focused on in-vitro and pre-clinical assessment. This is an excellent opportunity for an experienced scientist to take a technically influential role within a multidisciplinary environment, contributing to advanced pre-clinical testing capabilities across in-vitro science, product development and regulatory toxicology.
You will provide technical expertise and scientific direction across in-vitro Regulatory and Genetic Toxicology, supporting pre-clinical research, product development and regulatory programmes. The role will suit an experienced toxicologist with strong hands-on laboratory expertise who can work independently, lead technical activities and collaborate with internal teams and external partners.
Key Responsibilities
- Provide technical expertise in the development and application of in-vitro Regulatory Toxicology approaches.
- Lead and execute in-vitro studies, delivering robust, reliable and scientifically defensible data.
- Develop, optimise and apply Neutral Red, Ames and in-vitro micronucleus assays.
- Apply complex cell culture, exposure techniques and biological testing methodologies to investigate product safety and potential human health effects.
- Interpret experimental findings and bridge in-vitro data with analytical, human-use and clinical information where appropriate.
- Provide technical direction for new testing capabilities, methodologies and assessment strategies.
- Plan and deliver technical work programmes to agreed timescales, quality standards and objectives.
- Collaborate with multidisciplinary teams across Preclinical Science, Analytical Science, Toxicology, Clinical and Product Development.
- Build relationships with external technical partners, CROs, academic groups and specialist consultants.
- Support method transfer, validation and implementation of new technologies.
- Ensure data is generated and managed in line with appropriate quality and regulatory requirements within controlled, quality-assured laboratory environments.
- Contribute to continuous improvement of laboratory methods, processes and scientific capabilities.
- Prepare, author and peer-review scientific reports, technical documentation, regulatory materials, presentations and publications.
- Support external scientific collaborations, including method transfer and inter-laboratory validation.
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Experience & Skills Required
- Degree, MSc or PhD in Biological Sciences, Toxicology, Pharmacology, Biomedical Sciences, Cell Biology, Molecular Biology or a related discipline.
- Significant practical experience in in-vitro Regulatory Toxicology, Genetic Toxicology or pre-clinical area.
- Hands-on experience with Neutral Red, Ames and/or in-vitro micronucleus testing.
- Strong experience in complex cell culture, exposure techniques, biological assays and data interpretation.
- Experience developing, optimising, transferring or validating in-vitro testing methodologies.
- Understanding of relevant regulatory toxicology guidelines, including OECD, ECVAM and ICCVAM.
- Experience within a controlled, quality-assured laboratory environment, ideally with GMP, GLP or GxP.
- Ability to assess complex biological datasets using appropriate data analysis, computational or bioinformatics.
- Experience contributing to regulatory submissions, scientific reports, technical documentation or external scientific communications.
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Desirable
- Experience in disease modelling, molecular toxicology or adverse outcome pathway frameworks.
- Knowledge of bioinformatics, computational biology or advanced biological data analysis.
- Experience with high-content screening, high-throughput assays or innovative in-vitro platforms.
- Experience managing CROs, suppliers or scientific collaborations.
Benefits: Up to £70k + up to 30% bonus + 20% pension
To Apply: Please contact Alison Basson on 0203 909 3782 / 07814 547 440 or apply quoting ABJ6761 to alison.basson@hudsonshribman.co.uk
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