GSK
Principal Scientist - Protein Mass Spectrometry
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Job Title: Protein Mass Spectrometry Expert
Join the Extended Characterisation Europe team within Analytical Development and use your protein mass spectrometry expertise to help progress early-phase biopharmaceutical projects. This predominantly laboratory-based role sits at the interface of research and medicine development, generating analytical understanding that supports critical decisions on biotherapeutics, process development and product quality.
You will work in a high-performing scientific environment with exposure to multiple modalities and analytical technologies. This role offers the opportunity to deepen your protein characterisation expertise while collaborating across Discovery and CMC Development to help turn promising molecules into medicines.
Key Responsibilities:
- Perform analytical characterisation of biotherapeutics using mass spectrometry and chromatography techniques to generate knowledge and enable project decisions.
- Develop, optimise and troubleshoot analytical methods, including workflows used to identify post-translational modifications and critical quality attributes.
- Support early-phase portfolio progression through activities such as technology transfer, forced-degradation studies and analytical strategy delivery.
- Plan and deliver high-quality experimental work, independently analyse complex data and communicate clear scientific conclusions.
- Collaborate across matrix teams in Discovery and CMC Development, contributing technical insight, reports and regulatory documentation.
- Maintain high standards of data integrity, scientific rigour, laboratory safety and effective documentation.
Requirements:
Basic Qualifications & Skills:
- PhD, MSc or equivalent experience in analytical science, biochemistry, chemistry or a related field, with application to biopharmaceuticals or other therapeutics.
- Strong hands-on experience setting up, running and troubleshooting mass spectrometry, including Orbitrap and/or Q-TOF platforms.
- Experience of LC-MS or LC-MS/MS and analytical chromatography for protein or therapeutic characterisation.
- Knowledge of protein biochemistry and the relationship between molecular structure, function and critical quality attributes.
- Ability to plan experiments and independently analyse, interpret and draw conclusions from complex analytical data.
- Effective technical communication, organisation and matrix-working skills, with commitment to data integrity, documentation and safe laboratory practice.
Preferred Qualifications & Skills:
- Knowledge of protein glycosylation and analytical workflows for N-linked glycan analysis.
- Experience in advanced MS workflows such as host-cell protein, sequence variant or glycopeptide analysis, or complex and emerging modalities.
- Experience with Protein Metrics, automated data-processing pipelines, data standards or digital MS workflows.
- Experience with data visualisation, statistics or programming tools such as Spotfire, Power BI, JMP, SIMCA, SQL, Python or R.
- Experience of liquid-handling automation, QbD approaches or control-strategy development.
- Adaptability across scientific areas, shared instrumentation and multiple therapeutic modalities.
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Benefits:
- Competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.
- Embrace modern work practices; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
Location:
- For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Ware. The location of this role will therefore subsequently change to Ware in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.
Closing Date for Applications:
- 13th October 2026 (COB)
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
Why GSK?
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
Skills:
Biopharmaceuticals, Bioprocessing, Cell Line Development, Chromatographic Analysis, Drug Development, Experimental Methods, Mass Spectrometry (MS), Method Development, Molecular Cell Biology, Pharmaceutical Industry, Pharmaceutical Manufacturing, Protein Biochemistry, Protein Characterization, Quality by Design, Regulatory Submissions, Simulation Models, Technical Writing, Technology Transfer
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
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GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at UKRecruitment.Adjustments@gsk.com where you can also request a call.
Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive
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