This role is a permanent position based in the Process Development Group in Deeside (North Wales). As a Process Development Scientist - Bio-conjugation, you will work across all stages from early research (non-GMP) through to full development of processes for clinical trials manufacture (cGMP regulated).

The position is laboratory based, and you will spend 80% of your time in the laboratory and 20% in the office. You will need to work accurately, to high quality standards and to tight timelines. You will work in a fast-paced environment and will have direct client contact. This requires clear communication of complex data sets via written and oral presentations as a regular requirement.

Responsibilities:

• Develop methods for and perform the conjugation of small molecules (e.g. cytotoxins and chelators) and polymers to antibodies and proteins using a number of chemical and enzymatic conjugation techniques.
• Characterise manufactured antibody and protein conjugates using HPLC and mass spectrometry.
• To perform broader process robustness, characterisation and optimisation studies.
• To support with process scale-up and ultimately transfer into manufacturing facilities.
• Support with formulation development and stability studies as required.
• Comply with all safety, health, and environmental requirements.
• Presenting data to clients and internal scientific teams.
• Keeping accurate records and document experimental results in laboratory notebooks.
• Planning your own work to meet project objectives in a timely manner.
• Taking part in laboratory housekeeping and contributing to general maintenance of laboratory equipment.
• Performing tasks accurately following protocols (standard operating procedures (SOPs) and risk assessments).