The University of Manchester
Research Associate
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Research Associate Position in the Trost Lab
The Trost Lab within the Division of Molecular & Cellular Function wishes to appoint a laboratory-based Research Associate to characterize bacterial phagosomes in macrophages by state-of-the-art proteomics techniques using our recent flow-cytometry based isolation approach. This position is funded for 24 months with a start date between September-December 2026.
Responsibilities
You will be responsible for:
- Isolation of primary murine macrophages and bone marrow-derived macrophages from mice.
- Infection of macrophages with Salmonella enterica spp. Typhimurium.
- Isolation of Salmonella vacuoles/phagosomes by flow cytometry.
- Sample preparation for proteomics and collaboration with our lab’s proteomics experts.
- Utilization of our data analysis pipelines in R.
About You
We seek a talented and enthusiastic post-doctoral scientist with a background in infection biology or either microbiology, molecular immunology, biochemistry, or cell biology. You should demonstrate:
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Essential Criteria
- Have, or be about to obtain, a relevant PhD (or equivalent)
- Extensive hands-on experience with infection of mammalian cells with bacterial pathogens.
- Excellent technical skills in core lab techniques and benchwork.
- Proven ability to use initiative to efficiently plan, optimise and progress project and communicate findings.
- At least one first author publication in an internationally recognized journal (or on repository).
Desirable Criteria
- Experience with Salmonella and the ability to make mutants.
- Experience with flow cytometry.
- Experience with macrophages.
- Proficient in handling and analysing large omics datasets using R.
Our Benefits
- Generous employer contribution pension
- 29 days annual leave plus bank holidays, along with Christmas closure
- Ride to work and EV car scheme available
For more information, please see University of Manchester Benefits. You can also find information on our Flexible and Hybrid working here.
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Enquiries About The Role, Shortlisting And Interviews
Name: Matthias Trost
Email Address: matthias.trost@manchester.ac.uk
General Enquiries and Administrative Support
recruitmentservices.people@manchester.ac.uk
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Applications close at midnight on the closing date.
Further particulars (with person specification) linked below.
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