University of Cambridge
Research Associate (Laurenti Lab) (Fixed Term)
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Applications are invited for a research associate to join Prof Laurenti's research group
The team combine state-of-the-art experimental and computational methods to study the unique biological and molecular properties of human Haematopoietic Stem Cells (HSCs) across the lifespan. A specific area of interest aims to investigate how somatic mutations acquired by HSC in the first decades of life alter HSC function and predispose to blood cancers and other age-related diseases.
The Role
The post holder will lead a project centred on how mutations in the coding and non-coding areas of transcription factors confer HSCs with a selective advantage and predispose to leukaemia. The scope of the project is to identify cellular and molecular mechanisms and novel therapeutic vulnerabilities for early intervention or even prevention of blood cancers.
The successful candidate is expected to:
- Lead on the project and conduct experiments independently.
- Contribute to the larger team and assist other lab members on communal tasks as/when required.
- Communicate their work in writing and oral presentations at internal meetings and conferences.
- Assist in the supervision of master-level students undertaking research projects in the team.
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Qualifications and Experience
Candidates should hold a PhD in a relevant field. They will have a strong background in haematology, leukaemia (including clinical/translational aspects) and HSC biology. Extensive experience with flow cytometry, primary tissue culture (ideally with HSCs) and CRISPR editing in primary human cells is required. The candidate should also possess expertise with analysis of genomics data. Familiarity with studying transcription factors and experience with animals models is desirable. Finally, they will have demonstrated scientific achievement with an excellent publication record. Proven track record of securing own funding is desirable.
Terms
- Start date: November 1st 2026.
- Duration: Fixed-term; funds for this post are available until 31 October 2027 in the first instance.
Additional Information
- Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check.
- Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,132) moving to Research Associate (Grade 7) upon confirmation of your PhD award.
- Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
- Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
- Please quote reference RB51037 on your application and in any correspondence about this vacancy.
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