Thermo Fisher Scientific
Scientist
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Work Schedule
Standard (Mon-Fri)
Environmental Conditions
Adherence to all Good Manufacturing Practices (GMP) Safety Standards
Job Description
Materials Performance Scientist (Bio-enhancement) – Stevenage/Ware, UK
Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission – to enable our clients to make the world healthier, safer, and cleaner.
Within our Analytical Services team, we have a functional service provider solution, which is an outstanding partnership that allows our customers to use the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company, all while maintaining full-time benefits.
Summarized Purpose
In this role you will perform Bio-enhancement and pre-formulation characterization studies to support oral formulation development. This will include performing in vitro performance analysis to assess improvements to solubility/bioassessability using a range of techniques and to explore sample preparation to improve bio-enhancement outcomes.
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This position is based at our client site in Ware, travel to the Stevenage site may also be required.
Responsibilities
- Perform screening assessment of various bio-enhanced formulation options using a variety of techniques including spray drying (SD), small scale hot melt extrusion (HME), lipid based formulations (LBFs) and size reduction via micronisation and cryo-milling.
- Perform physical characterisation using techniques such as differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), microscopy (Optical and Hot Stage), xray powder diffraction (XRPD), scanning electron microscopy (SEM), Raman spectroscopy, particle size analysis, rhelogy and viscometry.
- Perform in vitro performance analysis using HPLC, Mass Spectrometry, UV-Spectroscopy, dissolution, artificial membrane permeability
- Complete the write-up of experimental results on electronic notebook system, provide technical reports for all work conducted and present findings/recommendations to project leads/supervisors
- Participate in Lab meetings - raising safety and quality concerns and participate in management/housekeeping audit activities
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Education / Experience required
- B.S./M.S. degree in Analytical Science, Chemistry, Pharmacy, or equivalent industry experience, with minimum 1-3 years’ experience in a laboratory-based role, primarily in pharmaceutical industry.
- Experience of working to industry expectations for data integrity within a non GxP environment.
- Knowledge and experience of bio-enhancement techniques to improve drug solubility
- Knowledge and experience of in vitro characterisation methods such as solubility and dissolution
- Some knowledge and experience of solid state analytical methodologies such as X-Ray powder diffraction and Raman spectroscopy.
Our 4i Values
Integrity – Innovation – Intensity – Involvement
If you resonate with our 4i values above, and ultimately wish to accelerate the delivery of safe and effective therapeutics for some of the world’s most urgent health needs, submit your application – we’d love to hear from you
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