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Downstream Process Development Scientist
Permanent | Darlington | £26,939– £36,000 per annum + attractive benefits
About the Role
We are seeking a hands-on Downstream Process Development Scientist to join their bioprocessing team in Darlington on a permanent basis.
This is a practical, lab-based role focused on the design, development, and optimisation of downstream purification processes for advanced biologics. You will play a key role in delivering DSP activities across a range of modalities, including viral vectors and nucleic acid-based products, in a fast-moving and highly experimental environment.
Reporting into the DSP leadership team, you will be responsible for running experiments, solving problems, and adapting processes as projects evolve. This role suits someone who enjoys flexibility, iteration, and scientific creativity rather than rigid, highly constrained environments.
The role is based on-site in Darlington, working as part of an established DSP team of approximately 11 scientists.
What You’ll Be Responsible For
Downstream Process Development
- Design, develop, and optimise downstream purification processes for biopharmaceutical products
- Carry out hands-on laboratory experimentation and pilot-scale DSP runs
- Apply chromatography and filtration techniques to improve yield, purity, and robustness
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Chromatography & Filtration
- Operate and develop chromatography methods using ÄKTA systems
- Design and optimise and run chromatographic purification strategies
- Apply tangential flow filtration (TFF) and related DSP technologies
Analytical & Data Interpretation
- Analyse and interpret experimental data using techniques such as:
- ELISA
- HPLC / UPLC
- SDS-PAGE
- Maintain high-quality experimental records using ELN and document management systems
- Present experimental conclusions clearly for internal and external stakeholders
Collaboration & Laboratory Operations
- Work closely with upstream, analytical, and project teams to deliver customer programmes
- Contribute to the efficient operation of the DSP laboratory, including equipment care and maintenance
- Support scale-up, knowledge transfer, and process troubleshooting activities
About You
You are a practical downstream processing scientist who enjoys being in the lab and is comfortable working in an evolving, sometimes ambiguous research and development environment. You bring curiosity, adaptability, and a willingness to try different approaches — and you’re not phased by processes that aren’t fully defined from day one.
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You’ll bring:
- Demonstratable experience of planning and delivering complex laboratory technical work, data analysis and reporting
- Theoretical and practical knowledge in Biochemistry, Biologics Purification, Biochemical Engineering, and relevant analytical techniques
- Experience designing and optimising chromatography-based purification processes
- Familiarity with TFF, ELISA, and HPLC/UPLC techniques
- Flexibility to adjust working hours around experimental needs
Desirable (but not essential)
- Experience using ÄKTA chromatography systems
- Experience working with AAV, viral vectors, or DNA/RNA-based products
- Background beyond monoclonal antibodies (mAbs)
- Experience in early-stage, development-focused, or non-rigid GMP environments
Applicants from academia are welcome.
Why Join?
- A genuinely hands-on laboratory role with real scientific ownership
- Exposure to emerging modalities and advanced bioprocessing technologies
- A collaborative team that values experimentation and problem-solving
Location & Working Pattern
- Based on-site in Darlington
- Flexible working hours aligned to experimental requirements
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