GSK
Senior Medical Director, Oncology Clinical Development
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GSK Overview
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.
Find out more: Our approach to R&D
Position Summary
Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most — advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.
The Senior Medical Director, Oncology Clinical Development is a senior physician leader within the clinical programme team, providing medical oversight, strategic clinical insight, and a patient-centred perspective across the design, conduct, and interpretation of clinical studies. This role ensures that medical considerations, patient safety, and clinical integrity are consistently applied across studies within a programme.
Operating within the clinical strategy defined by the Clinical Development Lead (CDL), the Senior Medical Director partners closely with the Senior Scientist and cross-functional teams to guide the integration of physician expertise into study execution and programme-level decision-making. The role serves as a senior member of the Clinical Matrix Team (CMT), contributing to complex clinical decisions, regulatory interactions, and external scientific engagement.
The Senior Medical Director provides oversight and guidance to Medical Directors within the programme, supporting consistency of clinical judgement, safety evaluation, and medical interpretation across studies.
In This Role You Will:
- Serve as a senior physician leader within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretation
- Provide guidance on medical monitoring and safety oversight across studies, ensuring consistent application of clinical judgement and patient safety standards
- Interpret complex clinical and safety data, generating insights that inform programme-level decisions led by the CDL
- Partner with the Senior Scientist and cross-functional teams to ensure medical considerations are integrated across study execution and programme delivery
- Provide senior medical input into protocol development and study design, ensuring clinical relevance and patient-centred design within the clinical strategy defined by the CDL
- Serve as a senior member of the CMT, influencing study-level and programme-level decision-making
- Engage with investigators, Key External Experts (KEEs), and scientific leaders to support external engagement and represent the programme at advisory boards, steering committees, and scientific forums
- Provide medical guidance and mentorship to Medical Directors within the programme, supporting consistency and development of clinical capability
Detailed Responsibilities:
Medical Monitoring and Safety Oversight
- Consistency in approach, patient safety, and protocol adherence
- Guide interpretation of safety data in collaboration with pharmacovigilance, supporting signal detection, escalation, and benefit–risk evaluation across the programme
- Participate in and contribute to safety review forums (e.g., SRT, IDMC), providing senior physician perspective on complex safety questions
- Ensure medical monitoring approaches are aligned across studies and consistent with regulatory and organisational standards
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Study Design and Execution
- Provide senior medical input into protocol development across studies, ensuring clinical relevance, feasibility, and alignment with the clinical strategy defined by the CDL
- Guide clinical aspects of study design and protocol implementation, particularly for complex, high-risk, or multi-study programmes
- Support resolution of complex medical questions arising during study conduct, applying clinical judgement to inform programme-level decision-making
- Ensure consistency of medical considerations across multiple studies within the programme
Data Interpretation and Scientific Contribution
- Interpret complex clinical data across studies, integrating findings to inform programme-level insights on safety, efficacy, and patient impact
- Contribute to programme-level data interpretation and support CDL-led benefit–risk assessment and clinical positioning
- Guide development of scientific communications, including publications, congress materials, and clinical summaries
- Maintain deep understanding of disease biology, evolving treatment paradigms, and competitive landscape to inform clinical interpretation and programme strategy
Regulatory and External Engagement
- Contribute senior medical expertise to regulatory interactions and Health Authority discussions, including responses to complex clinical and safety queries
- Represent the programme at advisory boards, steering committees, and external scientific forums, providing senior physician perspective on clinical data and programme direction
- Engage with KEEs and scientific collaborators to support programme development, scientific exchange, and external credibility
- Lead or contribute to the clinical and technical diligence assessment of business development opportunities
Cross-Functional Collaboration and Clinical Matrix Team
- Serve as a senior member of the Clinical Matrix Team (CMT), influencing cross-functional alignment and programme-level decision-making
- Contribute medical expertise to disease area strategy, integrated evidence planning, and Medical Affairs discussions
- Collaborate across functions to ensure alignment on safety, data interpretation, and clinical positioning across the programme
- Lead or contribute to Oncology Clinical Development-wide initiatives and workstreams
People Leadership & Capability Development
- Provide oversight, guidance, and mentorship to Medical Directors within the programme, supporting consistency and quality of medical input across studies
- Support development of clinical capability within the medical team, including coaching on medical monitoring, data interpretation, and external engagement
- Contribute to talent development, performance discussions, and capability building within Oncology Clinical Development
Why You?
Basic Qualification
We are seeking professionals with the following required skills and qualifications to help us achieve our goals
- MD (or equivalent medical degree) with board certification or eligibility in oncology, haematology, or a related specialty
- Significant clinical and/or pharmaceutical experience in oncology clinical development, with depth across multiple studies or programmes
- Demonstrated experience in medical monitoring, safety evaluation, and clinical data interpretation across clinical studies
- Strong understanding of clinical development processes, GCP, ICH guidelines, and global regulatory frameworks
- Experience operating within cross-functional matrix teams and contributing to complex clinical and programme-level decisions
- Strong scientific communication and stakeholder engagement skills, with the ability to influence internal and external audiences
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Preferred Qualification
If you have the following characteristics, it would be a plus
- Deep experience in oncology clinical development across multiple studies or programmes, including Phase I–III
- Experience contributing to or leading aspects of regulatory interactions (e.g., IND, scientific advice, NDA/MAA)
- Demonstrated experience engaging with KEEs, advisory boards, and scientific communities in oncology
- Track record of scientific publications and congress presentations
- Deep understanding of oncology disease biology and the evolving treatment landscape across solid tumours and/or haematological malignancies
- Experience mentoring or providing oversight to other physicians within a clinical development organisation
- Experience contributing to clinical and technical diligence for business development opportunities
Work Location and Arrangement
This career opportunity requires an on-site office presence (minimum of two days per week) at one of GSK’s Switzerland (Zug), Poland (Warsaw), UK (Stevenage or London HQ) or US (PA or MA) sites.
Skills
Clinical Data Interpretation, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations, Strategic Direction
Compensation
If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,250 to $473,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.
In compliance with Ontario's provincial pay transparency legislation, this job posting includes a salary range to support equitable and informed hiring practices. The annual compensation for this role is CAD0 to CAD0, determined based on experience, qualifications, and internal equity. GSK is dedicated to promoting transparency and fairness throughout our recruitment process.
Salary ranges for other locations are shown because some markets have pay transparency laws that require salary information on job postings, and those locations are potential job sites for this role. If salary ranges are not displayed in the job posting for a specific location or country, the relevant compensation will be discussed during the recruitment process.
Polish Salary Range / Polski przedział wynagrodzenia: PLN 593,250 to PLN 988,750
The annual gross base salary range for new hires in this position is listed above for each applicable location. These ranges take into account a number of factors including the candidate’s skills, experience, education level and the market rate for the role. In addition, this position may offer an annual bonus and eligibility to participate in our share based long term incentive program which
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