Senior Scientist – Immunology / Translational Research

A leading pharmaceutical company is looking for an experienced Senior Scientist to join its Immunology Research team, working within the Resolution of Inflammation focus area. This is an exciting opportunity to support the progression and optimisation of therapeutic molecules within early clinical development, generating and analysing preclinical and translational data to support scientific decision-making and patient population selection.

The Role

You will work as part of multidisciplinary project teams, designing and delivering experiments to understand target biology, model pathogenic mechanisms and investigate the mechanisms of action of novel therapeutics.

Key responsibilities will include:

• Developing and running translational in vitro and ex vivo assays
• Working with primary human cells and tissues to develop relevant disease models.
• Using a range of techniques including immunology assays, stromal/tissue-resident cell assays, co-culture, 3D models, imaging, flow cytometry, protein and RNA extraction and analysis.
• Analysing and integrating large, complex datasets from multiple sources.
• Working with Bulk RNA-seq, single-cell RNA-seq, spatial transcriptomics and proteomics datasets.
• Contributing to scientific strategy and decision-making across drug discovery and early development programmes.