Senior Scientist, PBPK

Senior Scientist, PBPK with Expertise in Biopharmaceutics Modelling & Simulation

We are currently looking for a Senior Scientist, PBPK with expertise in Biopharmaceutics Modelling & Simulation to join a leading Pharmaceutical company in Kent, supporting drug development across all stages. This is an exciting opportunity for a highly motivated professional to contribute to innovative projects by applying mechanistic modelling approaches to predict in vivo drug performance and optimize formulations.

Based within a dynamic, multidisciplinary environment, you will collaborate closely with scientists across biopharmaceutics, formulation development, clinical pharmacology, and pharmacokinetics, leveraging your expertise to support model-informed decision-making and regulatory submissions.

This is an initial 12-month contract with a possible extension.

Key Duties and Responsibilities

Your duties as the Senior Scientist, PBPK will be varied, however the key duties and responsibilities are as follows:

• Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus, or equivalent software.
• Support prediction and assessment of oral absorption, food effects, bioavailability, formulation bridging, dissolution, and particle size specifications, including virtual bioequivalence.
• Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to inform project decisions.
• Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and validation.
• Support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.
• Communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
• Contribute to advancing modelling methodologies, automation, and integration of AI/ML-enabled predictive tools.