Scarlet Therapeutics Ltd
Senior Scientist (Process Development)
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Role: Senior Scientist (Process Development)
Company: Scarlet Therapeutics
Location: Science Creates Old Market, Midland Road, Bristol
Application closing date: 30th November 2026
Start date: negotiable
About Scarlet Therapeutics:
Scarlet Therapeutics is a biotechnology company developing transformative cell therapies. Building on more than a decade of world-renowned research in Bristol, UK, the team at Scarlet is pioneering unique technology to harness the potential of blood as medicine, positioning the company to become the global leader in the field of therapeutic red blood cells.
We offer a fantastic working environment that is part of Science Creates, a Bristol-based deep tech ecosystem, combining specialist incubator facilities, a network of strategic partners and a dedicated venture capital fund.
Job Overview:
We are seeking a dedicated and innovative Senior Process Development Scientist to join our dynamic team. The successful candidate will play a pivotal role in generating manufacturing processes for Scarlet’s red blood cell-based therapeutics. The role will also include the generation of novel cell lines required to produce the red blood cells. The candidate will have a strong background in mammalian cell culture, up-stream and down-stream process development and will help drive forward our innovative red blood cell-based technology.
Key Responsibilities:
- Invent, perform, develop and optimize mammalian cell culture processes for cell line generation and for the production and purification of red blood cells.
- Development of formulations to stabilise red blood cell therapeutics.
- Ensure all process development and cell line generation work is sufficiently documented to support regulatory submissions or intellectual property requirements when appropriate and all activities are conducted in accordance with company’s quality system.
- Implement rigorous quality controls to monitor cell lines integrity, viability and contamination risks to ensure the quality of any produced cell lines.
- Ensure that all Equipment is properly maintained and calibrated for use and maintained in accordance with company standards.
- Conduct risk assessments for all laboratory activities, identifying potential issues and implementing mitigation strategies to ensure product quality and safety.
- Characterisation of donor derived erythroid cell lines using various cell biology and molecular biology techniques.
- Help support and train other scientists and provide experienced user input into the development and improvement of such processes.
- Stay updated on the latest advancements in mammalian cell line research and integrate new methodologies and technologies when applicable.
- Regularly review and update laboratory SOPs (Standard Operating Procedures) to ensure alignment with appropriate quality standards.
- Generally adhere to applicable policies and procedure relating to working in the laboratory including adherence to documentation of activities in electronic laboratory notebooks.
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Key Requirements:
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- Minimum of 5 years' experience in mammalian cell culture and process development (upstream and downstream), mostly gained within a Biotechnology/Pharmaceutical setting.
- Familiarity with laboratory scale bioreactors and downstream filtration systems.
- Familiarity with analytical techniques related to cell culture, such as flow cytometry, ELISA, Western blotting.
- Excellent problem-solving and analytical skills.
- Strong verbal and written communication skills.
Preferred Experience:
- Strong understanding and experience of operating to a GMP standard.
- Familiarity with high-throughput screening methods and use of automation.
- Analysis of proteomic, lipidomic and metabolic data.
- Proficiency in molecular biology techniques such as PCR, qPCR, cloning, viral transduction and transfection.
Scarlet Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering a diverse and inclusive work environment. We believe in the power of diverse perspectives to drive our innovation and progress. To qualify for this position, you will need to be authorized to live and work in the UK.
In your application, please send a CV and a covering letter stating your motivations and what you think you could bring to the role to leanne.parks@scarlet-tx.com.
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