Carbometrics
Senior Scientist – Synthetic Chemistry
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Senior Scientist – Synthetic Chemistry
Location: Science Creates St Philips, Bristol, UK (On-site, full time)
Position: Full Time (37.5 hours/week)
Closing date: 28th September 2026 (unless filled earlier)
Salary: £34,000–£39,000
Expected start date: ASAP
Company Profile
Carbometrics is a Bristol-based chemistry company specialising in the design and synthesis of highly selective binding molecules for use in cutting-edge sensors across hospitals, medical devices, bioprocessing, and industrial applications. Our mission is simple: to help people with diabetes and other conditions live longer, more comfortable lives by improving real time monitoring of key analytes such as glucose.
Built on over 20 years of pioneering research from Professor Anthony Davis' group at the University of Bristol (see: Davis et al., Nature Chemistry, 11, 52-56, 2018), our proprietary Biomimetic Glucose Binding Molecules (GBMs) underpin a glucose sensing platform capable of delivering a market-leading Continuous Glucose Monitor (CGM). The same core technology, developed through our predecessor company Ziylo, was acquired by Novo Nordisk to develop smart insulins (see: Slaaby et al., Nature, 634, 944-951, 2024). We have since expanded into a broader analyte portfolio including potassium, lactate, pH, CO₂, and calcium, building toward the most comprehensive continuously monitored sensor array for medical use.
About the Role
In the last 12 months, Carbometrics has developed and optimised an assay for the quantitation of glucose and other select analytes in complex media such as interstitial fluid, whole blood, and industrial cell culture fermentations. As we move further down the path towards a commercial device, one challenge we face is the large-scale synthesis of the assay components.
The successful candidate will use their synthetic chemical, analytical, and problem-solving skills to interrogate and, where necessary, modify current synthetic routes to improve yield and amenability to larger-scale synthesis. They will also be involved in numerous blue-sky research projects in progress at Carbometrics.
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To thrive in this role, the candidate must be able to work independently, be adaptable to new ideas and change, and be resourceful and self-motivated. Carbometrics is a young, growing company and will offer the successful candidate an interesting and enjoyable work environment with a highly motivated team of scientists, plus an opportunity to grow and develop scientific skills and experience.
Qualifications
A PhD in Synthetic Chemistry, or a Masters with an additional 3+ years' experience is required.
Job Description
As a Senior Scientist in Synthetic Chemistry, you will be responsible for:
- Designing and conducting laboratory experiments in a safe and efficient manner, often working under a Quality Management System (QMS) or Good Laboratory Practice (GLP)
- Optimisation of the synthesis and purification of small molecules on a large scale
- Analysing experimental data using relevant software (e.g. MNova) and maintaining an electronic record of experiments (MBook)
- Using instrumentation such as spectrometers (NMR, UV Vis, fluorescence), purification (Biotage, LCMS, HPLC, size exclusion, GPC), and biophysical techniques such as ITC, BLI, etc.
- Contributing to scientific discussions and offering suggestions to push forward new projects
What We're Looking For
- Qualification at postgraduate level (PhD, or Masters with an additional 3+ years' experience) in Synthetic Chemistry
- Extensive hands-on experience in laboratory settings and knowledge of purification and analysis methods for molecules of varying molecular weight and polarity
- Aptitude for troubleshooting experimental issues, root cause analysis, interpreting data, and designing alternative approaches to achieve research objectives
- Eagerness to stay informed about new techniques, technologies, and advancements in the field of chemistry, with the ability to quickly incorporate them into practical work
- Collaborative attitude and someone who works well within a highly skilled team
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Why Join Us?
- Gain valuable hands-on experience in practical chemistry and biochemistry with real application
- Work in a fast-paced startup environment where your work directly contributes to the company's objectives
- Opportunity to work on groundbreaking new research directly relevant to healthcare
- Competitive salary, workplace benefits, and flexible work terms
Eligibility and Expectations
To qualify for this position, you will need to be authorised to live and work in the UK. You must have respect for others and a commitment and enthusiasm for high standards and continuous improvement.
At Carbometrics we value diversity. We are an equal opportunities employer and welcome employees who meet the requirements of the job, regardless of gender, ethnic origin, disability, age, religion, or sexual orientation.
Important Information Regarding Your Application
Please note that we will not be confirming receipt of applications. Please include in your application confirmation of your consent for Carbometrics to hold your information and personal details for recruitment purposes. Applications without consent will be discarded.
Regarding your application, the following procedure will be followed:
- Carbometrics will keep records of your application strictly for recruitment purposes
- Any recruitment documentation will be kept for 12 months following the job position being filled
- The successful candidate's recruitment documentation will be kept in accordance with Carbometrics' Internal Personal Data Policy
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