SRG
Senior Scientist
Get notified of more jobs like this · No spam, ever
How your CV stacks up
Upload your CV to see how well it fits this job role
?%
Senior Scientist, Biopharmaceutics Modelling & Simulation (PBBM/PBPK)
Location: Sandwich, Kent
Rate: £20.66 per hour PAYE | £23.15 per hour Umbrella
Job Type: 12-month contract
Role Summary
We are seeking a highly motivated Senior Scientist with expertise in Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modelling (PBBM) to support the development and optimization of innovative drug products across all stages of development.
The successful candidate will apply mechanistic modelling and simulation approaches to understand and predict the impact of drug substance properties, formulation design, dissolution, physiology, and clinical variables on in vivo performance and patient outcomes.
The scientist will work within multidisciplinary project teams and collaborate closely with scientists in biopharmaceutics, formulation development, clinical pharmacology, and PDM (Pharmacokinetics, Distribution and Metabolism) to support model-informed drug development and regulatory decision-making.
Key Responsibilities
- Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus, or equivalent software.
- Support the prediction and assessment of oral absorption, food effect, bioavailability, formulation bridging, dissolution and particle size specifications, and virtual bioequivalence.
- Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support project decisions.
- Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and verification.
- Support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.
- Communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
- Contribute to innovation in modelling methodologies, automation, and data-driven approaches, including AI/ML-enabled predictive tools where appropriate.
Reasons to use Rodeo
Start with a chat, not a search bar
Grad scheme, placement, apprenticeship? Not sure what you want yet — that's fine. Your agent talks it through with you and turns "I have no idea" into a shortlist.
It searches the market for you
Every day your agent scans the market matching roles against what actually matters to you, not just keywords on a CV.
Only hits
No noise. No "maybe this fits." Just roles with a clear explanation of why they're right — and where to focus when applying.
Required Qualifications
- PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering, or a related scientific discipline. For MSc candidates, substantial relevant industrial experience in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development is required.
- Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.
- Strong understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.
- Experience with PBPK/PBBM modelling software such as Simcyp, GastroPlus, PK-Sim, or similar platforms.
- Demonstrated ability to apply modelling to solve pharmaceutical development challenges.
- Strong written and verbal scientific communication skills.
- Evidence of scientific productivity through publications, presentations, technical reports, or regulatory contributions.
Get help with your application
Your very own career expert that helps elevate your application to the next level.
Preferred Qualifications
- Experience supporting regulatory submissions involving PBPK or PBBM analyses.
- Experience with virtual bioequivalence or clinically relevant dissolution specifications.
- Working knowledge of Python, R, MATLAB, or other scientific programming tools.
- Experience applying machine learning or data science approaches to pharmaceutical development.
- Experience across multiple drug modalities, including poorly soluble compounds, enabling formulations, peptides, or complex dosage forms.
“It took my CV and asked me questions relevant to understanding what kind of jobs to suggest for me. Suggestions were almost perfect. Jobs were exactly what I’ve been looking for.”
Jessica, London
Skills
Location