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Study Of Tissue Iron Uptake In Iron-Deficient Patients Receiving Intravenous Iron Replacement Therapy A Prospective Observational Study
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Age: 18 Years +
All Genders
ID: 05609318
Study of Tissue Iron Uptake in Iron-Deficient Patients Receiving Intravenous Iron Replacement Therapy
A Prospective Observational Study
Led by: University of Oxford
Updated on: 2026-05-11
12 Participants Needed
1 Research Sites
Total Duration
On this page
- AI-Summary
- Brief Title
- Who Can Participate
- AI-Screening
- Your Study Journey
- Trial Site Locations
- How is the study designed?
- Similar Trials
- Frequently Asked Questions
AI-Summary
What This Trial Is About
Researchers are studying iron-deficient patients to track how iron moves into different body tissues after an intravenous iron infusion. This observational study focuses on understanding the timing and amount of iron uptake in organs like the heart, liver, spleen, kidney, and muscles, using MRI scans and blood tests. The study is conducted by the University of Oxford and aims to improve knowledge of iron distribution after treatment. Participants receive an intravenous iron infusion Ferric carboxymaltose, Ferinject, 1000mg as part of their usual medical care. The study does not alter this treatment but follows patients over time to observe iron in tissues. Four MRI scans occur at baseline before infusion, 3 hours, 14 days, and 42 days after the infusion. Blood samples are taken at these same times to measure iron levels and markers of tissue iron damage. During the study, participants will attend visits for MRI scans and blood collection at the Oxford Centre for Clinical Magnetic Resonance Research. Researchers will measure iron uptake kinetics in various tissues and evaluate changes in blood iron markers. The study tracks participants for about six weeks after their iron infusion to gather detailed information on iron movement and effects in the body.
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CONDITIONS
Brief Title
Imaging Intravenous Iron
Who Can Participate
Age: 18 Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Participant is willing and able to give informed consent for participation in the study.
- Aged 18 years or above.
- Have anemia (hemoglobin less than 120g/L for women and less than 130g/L for men) and/or confirmed iron deficiency (ferritin less than 100mcg/L and/or transferrin saturation less than 20%).
- Scheduled to receive intravenous iron for correction of iron deficiency.
You will not qualify if you...
- Have any MRI incompatible implants such as cardiac, neuro, ocular implants, surgical clips, aneurysm clips, or metal fragments.
- Pregnant or lactating.
- Have acute decompensated heart failure.
- Have unstable clinical status.
- Have any other medical conditions that would affect the study results as determined by the investigators.
- Have any other contraindications to MRI, including tattoos containing metal traces confirmed by the MRI operator.
AI-Screening
AI-Powered Screening
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Your Study Journey
Screening
Duration: 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration: 42 days
Participants undergo MRI scans and blood sample collection to assess tissue iron uptake and serum iron parameters.
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4 visits (baseline, 3 hours, 14 days, and 42 days post-intravenous iron infusion)
Trial Site Locations
Total: 1 location
Oxford Centre for Clinical Magnetic Resonance Research (OCMR)
Oxford, Oxfordshire, United Kingdom, OX3 9DU
Actively Recruiting
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Leaflet
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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On this page
- AI-Summary
- Brief Title
- Who Can Participate
- AI-Screening
- Your Study Journey
- Trial Site Locations
- How is the study designed?
- Similar Trials
- Frequently Asked Questions
Sponsors
U
University of Oxford
Lead Sponsor
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