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Transcranial Magnetic Stimulation For The Treatment Of Tremor In Essential Tremor And Parkinsons Disease
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Actively Recruiting
Phase Not Applicable
Age: 18 Years +
All Genders
ID: 07574164
Transcranial Magnetic Stimulation for the Treatment of Tremor in Essential Tremor and Parkinson's Disease
Led by University of Oxford
Updated on 2026-05-07
20 Participants Needed
1 Research Site
104 weeks Total Duration
On this page
- AI-Summary
- Brief Title
- Who Can Participate
- AI-Screening
- Your Study Journey
- Trial Site Locations
- Research Team
- How is the study designed?
- Similar Trials
- Frequently Asked Questions
AI-Summary
What This Trial Is About
Researchers are evaluating phase-locked transcranial magnetic stimulation (TMS) as a non-invasive treatment for tremor in people with Essential Tremor (ET) and Parkinson's Disease (PD). Tremor significantly affects physical ability and social participation, and current treatments like medications and deep brain stimulation have limitations including side effects and invasiveness. This study aims to reduce tremor by timing TMS pulses to specific phases of the tremor cycle, potentially improving tremor control in these conditions. The study includes two parts. In the first, participants with ET or PD undergo two visits where tremor is measured using sensors and TMS pulses are delivered over the motor cortex synchronized to tremor phases. The second part involves three additional randomized sessions testing stimulation at the most effective tremor-suppressing phase, a less effective phase, and sham stimulation. Each session lasts under two hours and uses devices to record tremor and apply TMS pulses at various timed intervals. Participants take part in multiple visits involving tremor recordings via inertial measurement units and electromyography, TMS delivery, and questionnaires assessing quality of life and tremor severity. Safety is monitored throughout, with participants able to withdraw at any time. The main outcome measured is the change in tremor amplitude during stimulation. Data is securely stored and analyzed to determine whether phase-locked TMS can reduce tremor in ET and PD patients.
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CONDITIONS
Brief Title
Closed-loop TMS for Tremor
Who Can Participate
Age: 18 Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Have a diagnosis of either Essential Tremor or Parkinson's Disease
- Be 18 years of age or older
- Be able to understand English
- Be able to provide informed consent
- Be eligible for transcranial magnetic stimulation based on safety screening
You will not qualify if you...
- Have contraindications to brain stimulation, such as epilepsy, metallic implants, pacemakers, or other conditions that make TMS unsafe
- Lack capacity to consent
- Have significant psychiatric or neurological illness that prevents participation
- Be currently participating in other research trials that would interfere with this study
- Have cochlear implants or intracardiac devices
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - Multiple visits over several weeks, each session lasting up to 2 hours
Participants undergo transcranial magnetic stimulation (TMS) delivered at different phases of tremor to evaluate its effect on tremor amplitude.
2 visits for initial phase determination and up to 3 additional visits for randomized stimulation sessions, each separated by at least one week
Trial Site Locations
Total: 1 location
-
Oxford Center for Integrative Neuroimaging
Oxford, Oxfordshire, United Kingdom, OX3 9DU
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Research Team
-
C
Charlotte Stagg
J Professor of Human Neurophysiology, MBBS
How is the study designed?
- Study Type: INTERVENTIONAL
- Masking: DOUBLE
- Allocation: RANDOMIZED
- Model: SEQUENTIAL
- Primary Purpose: BASIC_SCIENCE
- Number of Arms: 8
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Sponsors
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U
University of Oxford
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