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Utility Of PET-MRI In Post-Treatment Surveillance Of Paediatric Brain Tumours A Pilot Study
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Actively Recruiting
Phase Not Applicable
Age: 8 Years - 18 Years
All Genders
ID: 05553899
Utility of PET-MRI in Post-treatment Surveillance of Paediatric Brain Tumours: a Pilot Study
Led by: Sheffield Children's NHS Foundation Trust
Updated on: 2026-05-06
Participants Needed: 5
Research Sites: 1
Total Duration: 26 weeks
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- AI-Summary
- Brief Title
- Who Can Participate
- AI-Screening
- Your Study Journey
- Trial Site Locations
- Research Team
- How is the study designed?
- Similar Trials
- Frequently Asked Questions
- Sponsors
AI-Summary
What This Trial Is About
Researchers are exploring the use of PET-MRI for monitoring children treated for high-grade gliomas or medulloblastomas, which are malignant brain tumors common in pediatric patients. These tumors are challenging to manage due to difficulties distinguishing tumor recurrence from treatment-related changes using conventional MRI alone. The study aims to improve diagnostic accuracy and clinical management during post-treatment surveillance, particularly important for evaluating new therapies in early clinical trials. Participants will undergo PET-MRI scans that combine MRIs' detailed images with PET scans using the tracer 18F-fluodeoxyglucose 18F-FDG to detect metabolic activity associated with tumor cells. This imaging method may better differentiate between tumor recurrence and post-treatment changes compared to traditional MRI or PETCT scans. The study will assess the feasibility and impact of PET-MRI in diagnosing these brain tumors after treatment over a year. During the study, children will have PET-MRI scans and will be evaluated for their ability to complete the scan without general anesthesia. Researchers will measure how many patients can be recruited within one year, assess the acceptability of the procedure, and evaluate its accuracy. The study will monitor participants for at least one year to gather data on the effectiveness of PET-MRI in post-treatment surveillance.
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CONDITIONS
Brief Title
Utility of PET-MRI in Surveillance of Paediatric Brain Tumours
Who Can Participate
Age: 8 Years - 18 Years
All Genders
Eligibility Criteria
You may qualify if you...
- Have a presumptive or histologically confirmed diagnosis of a malignant brain tumour requiring treatment
- Diagnostic uncertainty about tumour recurrence post-treatment based on conventional MR imaging in the opinion of the MDT
- Have a life expectancy of at least three months
- Able to comply with an MRI scan without a general anaesthetic
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You will not qualify if you...
- Unable to comply with an MRI scan without a general anaesthetic
- Diabetes or other causes of hyperglycaemia
- Pregnancy
- Patient body habitus above scanner dimensions
- Standard contra-indication to MRI (e.g. pacemaker, non-compatible metallic implants, altered renal function)
Research Team
- David King, MBChB
- Keith Pugh, PhD
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On this page
- AI-Summary
- Brief Title
- Who Can Participate
- AI-Screening
- Your Study Journey
- Trial Site Locations
- Research Team
- How is the study designed?
- Similar Trials
- Frequently Asked Questions
- Sponsors
Sponsors
S
Sheffield Children's NHS Foundation Trust
Lead Sponsor
G
GE Healthcare
Collaborating Sponsor
U
University of Sheffield
Collaborating Sponsor
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