GSK
Associate Director / Director, Quantitative Systems Pharmacologist Lead
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Associate Director / Director, Quantitative Systems Pharmacologist Lead
The Department of Clinical Pharmacology and Quantitative Medicine (CPQM) in the GSK Respiratory, Immunology and Inflammation Research Unit is recruiting for a Quantitative Systems Pharmacologist Lead to join the Quantitative Systems Pharmacology team. At GSK, CPQM is a newly established organization with the remit to become a Centre of Excellence in Model-Informed Drug Development (MIDD). It uniquely integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic & systems modeling.
The convergence of science and technology is changing discovery and development at GSK, allowing us to make advances on behalf of patients that were once thought impossible. Our R&D organization is delivering more innovation, better and faster, using new data and platform technologies that speed up discovery and development and improve the chance of success.
This position represents a key opportunity for professionals with PhD, MD, PharmD or equivalent doctoral background, who are experienced mechanistic modelers with experience in QSP and/or QST modeling, clinical pharmacology and pharmacometrics to advance the vision and mission of GSK’s rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio. Sought after experiences for this position include building mechanistic mathematical models and leveraging knowledge in the areas of scientific ML, inverse problems, AIML and/or statistical methodologies, to enhance the robustness and quality of model development to leverage for decision-making from exploratory research through clinical development. You will be expected to play a critical role in the day-to-day driving integration of end-to-end model-informed drug discovery and development through building and applying QSP and QST models. In addition, you will be defining, implementing and coordinating QSP and QST related Clinical Pharmacology and Quantitative Medicine development strategies for disease and therapeutics of interest, and providing expert input into the clinical pharmacology evidence generation and integrated evidence plans in the Disease therapeutic area.
This is an exciting opportunity to bring your vision and leadership to a new era of digital innovation in clinical pharmacology and quantitative medicine, profoundly impacting patient outcomes and shaping the future of R&D at GSK.
Main responsibilities and accountabilities also include:
Build and/or guide mathematical model development to understand disease, its progression, and drug action to prevent, treat and cure diseases; conduct simulations to assess trial design performance Apply mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalities Develop and/or utilize state-of-the-art mathematical tools including knowledge of inverse-problem modelling and simulation, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction Define and execute a coordinated scientific and technical strategy (18-24 months planning horizon) with demonstrated ability to co-ordinate outputs from several expertise areas to determine strategy Work in close collaboration with biologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanisms Implement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipeline Create a collaboration framework with internal and external experts in the development and application of these models Learn and apply emerging modeling and simulation methodologies with a view to enhance clinical program efficiency and investment decision quality; collaborate with external field- leading teams for methodology application Able to efficiently and effectively interact with line and middle management, staff and external contacts on a functional, strategic and tactical level Represent QSP CPQM on various internal advisory boards, companywide initiatives and/or leadership teams Promote transparency and communicate R&D achievements through publications in appropriate scientific journals
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Why you?
Basic Qualifications:
PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology with applications in pharmaceutical research and development Minimum 5 years of experience in mechanistic mathematical modeling, inverse problem modeling and simulation, and/or scientific machine learning methodologies to be applied to pre-clinical and/or clinical questions in drug development to solve practical problems in the pharmaceutical industry Experience working with senior stakeholders in a cross functional environment Track record of implementation of Model-Informed Drug Discovery and Development (MIDD) approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugs
Preferred Qualifications:
Strong drive and agility to quickly learn and build knowledge on a drug-disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design Demonstrated aptitude for productive collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results Clear evidence / experience in making sound judgement in complex situations and adapting to changing business needs by prioritizing multiple tasks Prior experience in Hepatology and/or Cardiometabolic diseases is a plus
Why GSK?
Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
Agile and distributed decision-making – using evidence and applying judgement to balance pace, rigor and risk, governance and control, managing ambiguity and paradox Managing individual performance Creating a performance culture and driving results, prioritization, execution, delivering performance
Setting strategic direction and leading on-going organizational transformation
#Hybrid^
If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $188,100 to $313,500. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.
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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - usrecruitment.adjustments@gsk.com.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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