Insmed Incorporated
Associate Director DMPK
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Associate Director DMPK
Associate Director DMPK (Discovery DMPK Project Lead) – Cambridge, UK
At Insmed, every moment and every patient counts—and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. Our commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.
For patients, for each other, and for the future of science, we’re in. Are you?
About the Role
Insmed is shaping its Drug Metabolism and Pharmacokinetics (DMPK) capabilities in Cambridge, UK, to accelerate the progression of our growing pipeline of small molecule and antisense oligonucleotide (ASO) therapeutics. We seek a dynamic and experienced Associate Director DMPK to lead this exciting initiative.
As a Discovery DMPK Project Lead, you will:
- Represent DMPK across multidisciplinary drug discovery teams, applying your ADME and PKPD expertise to drive projects toward successful development candidate nomination.
- Act as a critical bridge between early Discovery and preclinical development.
- Collaborate with chemistry, biology, and informatics teams to leverage advanced modelling and simulation tools for data-driven decision-making.
This is an unparalleled opportunity to help establish and shape DMPK as a core Discovery discipline in a rapidly growing team. You’ll contribute to:
- Defining and refining the UK DMPK strategy.
- Influencing project direction and decision-making.
- Strengthening collaborations with our US DMPK team and external CROs.
- Building a high-performing Discovery DMPK function.
What You’ll Do
- Collaboratively develop and refine UK Discovery ADME and PKPD strategies.
- Design and interpret nonclinical ADME studies to guide molecule optimization and predict human drug disposition.
- Work with chemistry teams to assess and mitigate development risks, using insights from ADME, DDI, and safety data.
- Collaborate with biology to ensure therapeutic drug exposure confidence through analysis of in vitro and in vivo pharmacology.
- Partner with informatics to apply PK, PKPD, and PBPK modelling (e.g., Phoenix WinNonlin, Simcyp, GastroPlus) for accurate human PK projections.
- Provide critical datasets, expertise, and decision-making insight to drive candidate selection, safety margins, and dose optimization.
- Foster strong CRO partnerships to expedite quality DMPK study delivery.
- Engage closely with discovery and US-based teams to align DMPK strategies across sites.
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Who You Are
Required Qualifications
- PhD in Pharmacokinetics, Pharmacology, Biochemistry, or related pharmaceutical sciences.
- Minimum 8 years of DMPK experience in biotech or pharmaceutical, ideally with smaller, dynamic organizations.
- Proven ability to lead DMPK contributions in cross-functional discovery projects, resulting in successful clinical candidate nominations.
- Deep expertise in nonclinical ADME, safety, and DDI study design, execution, and interpretation, along with human PK and dose projection skills.
- Strong track record of managing CRO relationships and facilitating value-adding cross-functional collaborations.
Additional Critical Skills
- Exceptional communication, critical thinking, and problem-solving mindset.
- Experience working in a paperless, data-driven, and fast-paced drug discovery environment.
Hybrid Working
This role is based in state-of-the-art offices and labs at Babraham Research Campus, South Cambridge, with hybrid working flexibility available based on team requirements.
Desirable Qualifications
- Experience with ASO therapeutics (or CBI drugs).
- Hands-on experience with PK, PKPD or PBPK modelling (e.g., Phoenix WinNonlin, Simcyp, GastroPlus).
- Familiarity working with CNS-targeted small molecules.
Inside Insmed
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Our Cambridge research hub is situated on Babraham Research Campus, a global leader in bioscience innovation. We combine multidisciplinary expertise—from genetics to computational chemistry—to transform the future of patient care.
At Insmed, culture is as human as our mission. Your workplace reflects care, growth, and balance, with:
- Support for how you thrive professionally and personally.
- Approaches that value your mind, well-being, and time with patients and colleagues.
Benefits We Offer
- Flexible work schedules ensuring regular in-person collaboration.
- Competitive retirement benefits, global equity awards, and Employee Stock Purchase Plan (ESPP).
- Career development, including our Insmed Learning Institute, LinkedIn Learning, and role-specific workshops.
- AI-powered learning tools and an internal assistant platform for seamless internal discovery.
- Hybrid-friendly technology to enable effective global teamwork.
- Global recognition programs and Employee Resource Groups.
Existing employees: Apply via the Jobs Hub in Workday.
Insmed Commitments
- An Equal Opportunity employer: We promote diversity and inclusion, providing equal opportunity without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, age, or any other legally protected trait.
- Agencies should only submit candidates with a formal agreement in place—unsolicited resumes may not be considered. All recruitment activities are managed by HR (TotalRewards@insmed.com).
Reasonable Accommodation Contact
Insmed is committed to accessibility and inclusivity. To request accommodation for the application or interview process: 📩 Email: TotalRewards@insmed.com 📩 Subject: Request: Reasonable Accommodation for Job Application
Requests will be evaluated on a case-by-case basis.
Inquiries pertaining to reasonable accommodation requests will only be addressed via this email.
Applications accepted for 5 calendar days from posting or until the position is filled.
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