Barrington James
Associate Medical Director
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Associate Medical Director – Site Network (UK)
60% Principal Investigator (PI) Work / 40% Operations & Site Growth
Role Overview
We are seeking a clinically active Associate Medical Director to join a growing UK clinical site network. This hybrid role combines hands-on Principal Investigator (PI) leadership (60%) with strategic operational and site expansion responsibilities (40%).
You will play a key role in driving high-quality clinical trial delivery, ensuring patient safety, scientific integrity, and regulatory compliance, while also supporting the growth, performance, and scalability of the site network across the UK.
Key Responsibilities
Principal Investigator / Clinical Delivery (60%)
- Act as Principal Investigator (PI) on assigned interventional clinical trials across multiple therapeutic areas (with emphasis on oncology, haematology, and complex chronic disease studies where applicable)
- Ensure full compliance with ICH-GCP, UK regulatory requirements, and study protocols
- Oversee patient eligibility, informed consent, safety oversight, and medical decision-making
- Provide medical leadership on protocol feasibility, amendments, and study conduct
- Lead investigator oversight visits, sponsor interactions, and audit/inspection readiness
- Support and mentor sub-investigators and site clinicians to maintain high-quality delivery
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Site Operations & Growth (40%)
- Support expansion of the UK site network footprint, including identification of new site opportunities
- Contribute to site start-up strategy, feasibility assessments, and pipeline prioritisation
- Work closely with operations teams to improve recruitment performance, activation timelines, and retention
- Build and maintain relationships with sponsors, CROs, and strategic partners
- Support development of standardised processes across sites to improve efficiency and quality
- Provide clinical input into business development proposals and feasibility pipelines
- Help shape the medical and operational strategy of the network
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Key Requirements
- GMC-registered physician with active licence to practise in the UK
- Strong background in clinical trials (industry or academic setting)
- Prior experience as Principal Investigator (PI) or Sub-Investigator
- Solid understanding of ICH-GCP, MHRA expectations, and clinical research governance
- Demonstrated ability to balance clinical responsibility with operational leadership
- Excellent communication skills with ability to engage investigators, sponsors, and internal teams
- Strong organisational and decision-making capability in fast-paced environments
What This Role Offers
- Hybrid role combining hands-on patient-facing PI work with strategic leadership
- Opportunity to shape and scale a rapidly growing UK site network
- Direct impact on trial delivery performance and patient access to innovation
- High visibility role with influence across clinical operations and business growth
- Collaborative environment with strong focus on quality and scientific integrity
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