Roche
Clinical Pharmacology Lead - Expert Scientist
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Senior Expert in Clinical Pharmacology (Model-Informed Drug Development)
At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.
The Position
Join Roche, where every voice matters.
In Roche’s Pharmaceutical Research and Early Development (pRED) organisation, we make transformative medicines for patients to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines.
Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward ext ordinaire, life-changing innovation at speed.
At the intersection of science and innovation, the Pharmaceutical Sciences (PS) organisation enables the discovery and development of safe and effective therapeutics at optimal doses in relevant populations. With the vision to power translation, and continuously improve the accuracy of our predictions, it accelerates the development of tomorrow's medicines. By seamlessly integrating three core pillars—Translational Safety, Translational Pharmacology, and Biomarkers—we drive end-to-end asset development across the entire value chain, from target assessment to on-market support.
The Opportunity
This position is within the Clinical Pharmacology Section in the Quantitative Clinical Pharmacology Department in pRED / Pharmaceutical Sciences, but maintains a company-wide footprint.
The scope of influence transcends individual teams, regularly partnering across major organisational boundaries and cross-entities (e.g., pRED, gRED, PDR) to shape institutional knowledge.
In this role, you will serve as a senior enterprise leader and expert in Clinical Pharmacology, including Model-Informed Drug Development (MIDD) and Quantitative Medicine. You will:
High-Impact Strategic and Scientific Leadership
- Formulate and evolve overarching Clinical Pharmacology and MIDD strategies for high-profile molecules or portfolio segments (e.g., Antibody-Drug-Conjugates) of Roche’s focus disease areas (CVRM, Immunology, Neuroscience, Oncology, and Ophthalmology).
- Ensure alignment with end-to-end development goals.
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Pioneering Technical Innovation
- Identify, develop, and integrate state-of-the-art computational methodologies into workflows.
- Stimulate the broader scientific community to experiment and challenge development paradigms.
Complex Submissions & Regulatory Defence
- Provide authoritative guidance on highly complex or unprecedented submission strategies (e.g., pediatric extrapolations, novel modalities).
- Serve as a primary counterpart to health authorities and KOLs.
Strategic Business Development
- Lead Clinical Pharmacology and modelling evaluations and contribute to Clinical Development Plans.
- Actively participate in high-stakes due diligence, in-licensing, and out-licensing opportunities.
- Assess the path to value, technical viability, and risks of external assets.
Roche Ecosystem Engagement
- Actively participate in and drive pRED/Roche-wide initiatives to maximize organisational impact.
Culture Catalyst
- Serve as an inspirational role model, bringing teams together to create clarity, focus, and a high-performance environment.
Strategic Mentorship
- Actively coach and mentor Principal Scientists and Department members globally.
- Build deep quantitative and translational capabilities, integrating advanced quantitative approaches to drive development strategies and portfolio decision-making.
Global Influence & Collaboration
- Influence senior leadership, handle high-stakes conflicts with resilience, and effectively collaborate across diverse stakeholders.
Who You Are
Education
- Must hold a PhD, Pharm.D., or MD with a specialised focus in Pharmacometrics, Clinical Pharmacology, or a closely related scientific discipline.
Experience
- 10+ years of experience in the pharmaceutical or biotech industry in the area of Quantitative Clinical Pharmacology.
- Demonstrated documented track record of expert scientific contributions, successful regulatory approvals, and impactful matrix leadership.
- Strong understanding of the end-to-end development pathway—from early research through late-stage development and regulatory submission.
- Ability to translate scientific insights into impactful development strategies.
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Technical Skills
- Strong foundation in Clinical Pharmacology principles and quantitative drug development.
- Masterful, hands-on capabilities and understanding of multi-scale quantitative workflows and advanced modelling approaches across diverse therapeutic modalities.
Leadership & Influence
- Strong strategic thinking, embrace of innovation, ownership, and a proven ability to influence senior leadership.
- Ability to handle high-stakes conflicts with resilience, while actively shaping global organisational strategy.
Who We Are
A healthier future drives us to innovate. Together, more than 100,000 employees across the globe are dedicated to advance science, ensuring universal access to healthcare today and for generations to come. Our efforts impact:
- 26+ million people treated with our medicines
- Over 30 billion diagnostic tests conducted
We empower each other to explore new possibilities, foster creativity, and keep our ambitions high to deliver life-changing healthcare solutions with global impact.
Why Roche?
- Courage and passion: We transform patients’ lives through urgent medical solutions while exploring futures of innovation.
- Ethics and rigor: Committed to scientific rigor alongside unassailable ethics, and deliver access to medical innovations for all.
- One vision: Working as one across functions, companies, and continents, we are proud of who we are, what we do, and how we do it.
Roche is an Equal Opportunity Employer. Let’s build a healthier future, together.
Location
Basel (or additional locations disclosed later in the hiring process). If applicable, pay transparency will be provided based on the primary posting location.
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