University of Leeds
Clinical Research Fellow
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Clinical Research Fellow
Clinical Researcher Opportunity (Systemic Lupus Erythematosus)
Exclusively for University of Leeds staff
This role may be released externally if an internal appointment is not made.
About the Role
Are you an ambitious clinical researcher passionate about tackling autoimmune connective tissue diseases, particularly systemic lupus erythematosus (SLE)? This opportunity offers:
- A chance to pioneer research into biological therapies for SLE
- Opportunity to pursue a research degree
- Collaboration with a cutting-edge, highly talented faculty team
- Advancement within one of the UK’s leading research universities
The Challenge: SLE Research Gaps
Studies show SLE—a group of diseases with inflammation, type I interferon activity, and autoantibody production—disproportionately impacts children and non-European ancestries, often with poor prognosis.
Current standards:
- Treat with conventional immunosuppressants + glucocorticoids (GC), but optimal sequencing is unclear
- Currently, biological therapies like rituximab are only added after first-line treatments fail, despite higher mortality, GC exposure, and healthcare resource use in the first 12 months of diagnosis
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Our research focus:
- Compare clinical and cost-effectiveness of biological therapies as first-line vs. rescue therapy for moderate-severe SLE
- Optimise outcome measures/treatment targets for clinical trials and practice
- Explore immunophenotyping and skin biopsy methods
- Ensure systematic literature review and patient and public engagement are central
Key Duties ( Expectations )
You will:
- Independently lead studies in SLE, from methods development to clinical implementation
- Contribute to team priorities while driving your own research
- Take a leading role in developing robustzul sequential treatment approaches
Requirements Essential:
- Medically qualified with MRCP (or equivalent)
- Full GMC registration
- Prior experience in managing autoimmune connective tissue diseases (especially SLE)
Remuneration & Conditions for Junior Doctors/Dentists in Training
We adhere to NHS 2016 contract arrangements. Salary will depend on your current NHS training band (transitional arrangements).
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Benefits and Perks
- Holiday Entitlement: 26 days + ~16 Bank holidays/University closure days (42 days total)
- Pension: 21.6% University contribution + life assurance
- Health & Wellbeing:
- Discounted membership of The Edge, our premium campus gym (pool, sauna, indoor climbing, sports halls, cycle circuit)
- Personal Development:
- Access to professional learning courses through our Organisational Development & Professional Learning team
- Self-development workshops: languages, creative writing, wellbeing therapies, and more
- Additional benefits:
- Onsite childcare options
- Discounted shopping and travel schemes
Next Steps
Contact: Professor Edward Vital Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds & NIHR Leeds Biomedical Research Centre
📞 Tel: +44 (0)113 3438 412 ✉ Email: e.m.j.vital@leeds.ac.uk
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