Norvara Therapeutics
Computational Biologist & Co-Founder
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Computational Biologist & Co-Founder
Remote – Voluntary Computational Biologist & Structural Virology Researcher
(Pre-Seed / Pre-Startup, Co-founder Role) Location: Remote Area: Computational Biology / Structural Virology Company: Norvara
About the Role
This is a remote, voluntary co-founder opportunity for a Computational Biologist/Structural Virologist focused on designing and optimizing next-generation AAV capsid variants to address critical challenges in gene therapy.
You’ll leverage advanced computational architectures, deep learning, and structural biology expertise to:
- Translate vast evolutionary datasets into predictive models
- Engineer optimized capsid designs evading immunogenicity and improving tissue specificity
- Collaborate interdisciplinary teams bypassing traditional lab constraints
- Accelerate R&D from physical screening → in silico design
This role offers hands-on experience at the frontier of machine learning and structural biology within a highly academic, meritocratic startup setting.
Key Responsibilities
- Structural Engineering
- Develop AAV capsid variants using AI-driven predictions of specific structural folds
- Apply advanced computational methods to test and refine candidate designs
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Academic Translation & Model Generation
- Extract functional signals from noisy evolutionary datasets to inform novelty capsid designs
- Translate leading edge structural biology research into actionable modeling frameworks
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Performance Optimization
- Evaluate and iteratively improve capsid variants for:
- Tissue specificity (broad vs. targeted delivery)
- Immunogenicity mitigation (reducing natural antibody neutralization)
- Reduced production complexity (superior manufacturability)
- Evaluate and iteratively improve capsid variants for:
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Deep Learning Integration
- Build, test, and optimize ML models to replace Slow wet-lab screening with rapid computational simulations
- Focus on protein folding tasks and capsid-stability predictions
Qualifications
We seek exceptional candidates with:
- BSc, MSc or Ph.D in Computational Biology, Biophysics, Biochemistry, or related STEM fields
- RelevantARNES with:
- Protein language models (e.g. ESM, Tr Rosetta*)
- Deep learning frameworks (solutions-based—PyTorch preferred)
- Python for large-scale probabilistic modeling
- A strong theoretical foundation in:
- Mathematics & Statistics (for model robustness)
- Structural Biology/Virology (understanding capsid architecture)
- Problem-solving aptitude with expertise in using empirical biological data-driven approaches
- Passion for bridging translational medicine and AI—especially in gene therapy tools.*
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About Norvara
Founded by [Dr. CCX] ([GWU/CNLS Course Hoover, Ph.D. UCL), Norvara's mission is to redefine AAV capsid engineering using machine learning acceleration.
Our next-generation AAV constructs are designed for: ✅ Unprecedented site-specific delivery ✅ Thermostabilized production (simplifying delivery and versatility) ✅ Immunity-evasion (avoiding neutralizing antibodies)
With roots in academic excellence and outcomes in high-value gene therapy, Norvara is structured as Prof. CCX's group combined in lab partnership "with equity vested over five years." Each co-founder engages distinct domains (genetic, biochemical, bioinformatistics).
Do not apply to us. We will apply to you. ☺ Apply through this link
Text leader: Dr. CCX ([@@ Provides contact via LinkedIn/email]). We exclusively expand sequencing [Nor("", [Nor(AAV Verticals)]
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