AstraZeneca
Medical Director, Senior Patient Safety Physician
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Job Title: Medical Director, Senior Patient Safety Physician
Location: 3 days onsite in Luton, UK
Are you ready to lead patient safety innovation at the forefront of global healthcare? At AstraZeneca, we're not just developing tomorrow's medicines—we're reimagining how patient safety shapes every breakthrough. As a Medical Director and Senior Patient Safety Physician in our vibrant Luton hub, you'll join a collaborative network of world-class professionals who turn complex challenges into life-changing solutions. Here, your expertise doesn't just protect patients; it drives the strategic decisions that bring hope to millions worldwide.
We believe that exceptional patient safety requires exceptional minds working together across continents, combining pioneering science with unwavering integrity to ensure every innovation serves humanity's greatest need: safe, effective treatments that transform lives!
As a Medical Director, Senior Patient Safety Physician in Luton, UK, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact in changing patients’ lives. Oncology R&D global development drives our innovative pipeline, redefining science into valued new medicines and ensuring patients around the world can access them.
Main Duties and Responsibilities:
- Responsible for the Clinical Safety strategy for assigned drug projects and products throughout all stages of development and/or when on the market, including implementation and communication of the strategy at the project team/governance level.
- Continued safety assessment, evaluation, and risk management of AZ products or product groups in various stages of clinical development and/or the post-marketing setting.
- Continuous efficient evaluation of adverse event and all other safety information.
- Provide consistent communication of safety topics across all regulatory safety documents, e.g. Periodic Benefit Risk Evaluation Reports (PBRERs), Periodic Adverse Drug Experience Reports (PADERs), and Development Safety Update Reports (DSURs), for assigned product(s)/program(s).
- Proactively evaluate the clinical implications of safety data from pre-clinical studies, clinical studies, and literature to predict/establish the safety profile of compounds in clinical development.
- Employ expert groups and methodologies such as Safety Knowledge Groups (SKG’s), Safety Science, Informatics expertise, modeling, and simulation to manage the risk to patients.
- Involved in all safety surveillance activities, which may include:
- Medical review of individual safety cases (providing medical expertise and judgment)
- Signal detection, evaluation, and SERM activities for all products in the area of responsibility.
- Medical input and review of periodic reports (e.g., PBRERs, PSURs, or DSURs) and renewal documentation submitted to regulatory agencies.
- Patient safety contribution to global regulatory submissions (NDA, BLA, MAA, etc.) for new products, formulations, or indications.
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Essential Education, Experience, and Skill Requirements:
- Medical degree (e.g., MD, MBBS)
- 2 years+ of clinical experience post-registration
- High level of medical competence, with an ability to balance this with industry standards to achieve business goals
- 4 years+ of Drug Development/Patient Safety experience (the majority of which should be in industry in Patient Safety) with clear evidence of delivery
- Detailed knowledge of the pharmaceutical/biopharmaceutical industry, especially clinical research and global regulatory requirements (e.g., BLA, NDA, or MAA) and practices governing expedited and periodic safety reporting, signal generation, safety evaluation, and risk management activities
Preferred Education, Experience, and Skills:
- MSc/PhD in a scientific field
- Ability to work across TAs and Functions
- Experience leading and inspiring Patient Safety colleagues
- Demonstrated ability to understand epidemiological data
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace, and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility.
Join us in our unique and ambitious world. At AstraZeneca, patient impact drives every decision: a broad and rapidly evolving Oncology pipeline offers constant exposure to novel mechanisms, complex data, and innovative trial designs; cross-functional collaboration with global experts fuels learning; a culture that values courage, curiosity, and smart risk-taking empowers decisive action based on science; and continuous development opportunities support long-term growth while contributing directly to transforming cancer care worldwide.
So, what’s next: If this role matches your expertise and ambition, apply now to help shape the future of patient safety in Oncology.
***Please note: we operate a rolling recruitment process and may close this vacancy early if a strong candidate is identified. Early applications are strongly encouraged. Competitive salary and benefits package on offer. The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, a performance recognition scheme, and a competitive, generous remuneration package.
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Date Posted: 09-Jul-2026
Closing Date: 07-Aug-2026
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing, and commercializing prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention, and unleash your entrepreneurial spirit.
To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth, and development for all.
Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking.
We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions.
As an organization centered around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realize the full breadth of your potential.
Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day.
This is your life at AstraZeneca.
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