The University of Manchester
PDRA in vivo imaging
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PDRA in vivo imaging
Postdoctoral Research Position - Alzheimer's Disease Research
An exciting opportunity exists to carry out a postdoctoral research position in the newly established GSK-Manchester NaVigate programme to establish treatment options for Alzheimer’s Disease. The position will be initially available for 3 years, with the possibility of extending up to 5 years. The research will be carried out in the Microvascular@Manchester group (microvascularmanchester.com) under the guidance of Professor Adam Greenstein and Dr Harry Pritchard. The post will be based within the Division of Cardiovascular Sciences at the University of Manchester and the Geoffrey Jefferson Brain Research Centre.
The research follows on from the recent work from the Microvascular@Manchester group into the pathways underlying the reduction in cerebral blood flow in Alzheimer’s Disease (https://pubmed.ncbi.nlm.nih.gov/35727988/). The appointed person will work with cerebral arteries from mice, to discover the mechanism by which amyloid beta contracts vascular smooth muscle cells. The goal is to understand the underlying amyloid beta induced Ca2+ signals and identify therapeutic targets. By prevent these calcium signals we hope to improve arterial diameter control, thereby increasing cerebral blood flow and maintaining cognitive function. This research will utilise state-of-the-art in vivo imaging techniques and resources in the brain. As well as leading a project, the successful post-doctoral researcher will also be given fantastic opportunities to collaborate on other projects within the lab and/or within The Manchester British Heart Foundation Centre of Research Excellence.
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About You
We welcome candidates who bring diverse perspectives, experiences, and approaches to their work.
We encourage applications from individuals with a wide range of backgrounds and experiences. You should demonstrate:
Essential Criteria
- A PhD (or near completion) in neurovascular coupling, neuroscience or a related field
- Experience using multiphoton microscopy and intrinsic optical imaging to study brain vasculature in awake mice
- Experience with small animal models, including dementia research models and regulated procedures
- Strong data analysis and programming skills, with experience using relevant analytical software
- Evidence of scientific publication and excellent communication skills
Desirable Criteria
- Experience in electrophysiology, in vivo blood flow measurement or behavioural neuroscience methods
- Previous Home Office Personal Licence (PIL) or equivalent
- Experience supporting student supervision and training
- Experience working within collaborative interdisciplinary research environments
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Responsibilities
You will be responsible for:
- Performing multi-modal preclinical imaging, including multi-photon microscopy and 2D-OIS imaging
- Conducting behavioural experiments to assess cognitive function and undertaking histology and immunohistochemistry studies
- Extracting, analysing and managing experimental data using MATLAB, R and related software tools
- Preparing scientific publications, conference presentations and research outputs
- Supporting collaborative research activity, mentoring students and contributing to a positive research culture
Enquiries
Informal enquiries can be made to Prof Adam Greenstein.
Email adam.greenstein@manchester.ac.uk
Details
Closing date: 17/07/2026
Please quote reference BMH-031830
The University of Manchester values a diverse workforce and welcomes applications from all sections of the community
Please see Further Particulars and Person Specification below
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