Instruct-ERIC
Postdoctoral Research Assistant in Structural Biology
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University of Oxford, United Kingdom
Application deadline: 31 Jul 2026
We are seeking an ambitious Postdoctoral Research Assistant to join the laboratory of Dr Georgia Isom at the Sir William Dunn School of Pathology, University of Oxford, to uncover the molecular machinery that transports sphingolipids to the surface of Gram-negative bacteria. This exciting project combines cryo-electron microscopy, native mass spectrometry, proteomics, and bacterial cell biology to answer a fundamental question in bacterial membrane biology.
For decades, sphingolipids were thought to be almost exclusively eukaryotic membrane components, with only a handful of unusual bacteria capable of producing them. Our recent discoveries have overturned this view, revealing that sphingolipid biosynthesis is widespread across diverse bacteria. Emerging evidence suggests sphingolipids are key determinants of membrane homeostasis, environmental adaptation, antimicrobial resistance and host-pathogen interactions. Yet one of the biggest questions in the field remains unanswered: how are sphingolipids transported across the bacterial cell envelope to reach the cell surface?
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As the successful candidate, you will drive this project by combining structural and mechanistic approaches to identify and characterise sphingolipid transport systems. You will determine high resolution single particle cryo-EM structures of sphingolipid transporters. In parallel, you will assess sphingolipid-transporter interactions and the role of the sphingolipids in membrane homeostasis using a combination of mass spectrometry and cellular electron microscopy methods.
Key Requirements:
- Hold, or be close to completion of, a PhD in structural biology
- Experience of solving high resolution structures using single particle cryo-EM
- Highly motivated and organised
- Ability to work independently as well as part of a team
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This is a fixed-term appointment available for 2 years in the first instance (with funds to extend) with the position available from autumn/winter 2026. If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application. Informal enquiries could be sent to Dr Georgia Isom via email: georgia.isom@path.ox.ac.uk.
Only applications submitted online and received before noon Friday 31st July 2026 will be considered. Interviews will be held soon thereafter.
For more information and to apply, visit our website.
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