MRC Protein Phosphorylation and Ubiquitylation Unit
Postdoctoral researcher
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Postdoctoral Researcher
The Postdoctoral Researcher will work full time on-site in the MRC PPU, Dundee in the Swamy group, to explore the role of a disease-relevant kinase in B cell function in the gut.
This is a fixed-term appointment for 30 months, starting August 2026.
About the Role
This MRC-funded project will investigate the role of LRRK2, a key kinase and potential drug target for both Crohn's disease and Parkinson's disease, in intestinal immune homeostasis. Using in vivo models and primary human lymphocytes, the project will examine LRRK2 function in B cells, building on our previous findings of inflammation-dependent LRRK2 induction in B cells (Dikovskaya et al, 2025, PMID: 40394349), and the extensive local expertise in LRRK2 mechanistic studies (Alessi and Pfeffer 2024, PMID: 38621236). We aim to understand the role of disease-relevant LRRK2 mutations using patient samples and biochemical studies.
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Responsibilities
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The successful candidate will:
- Contribute to ground-breaking research that has strong translational potential
- Present the research in national and international meetings and publish findings
- Collaborate with multidisciplinary teams within MRC-PPU and external partners
- Contribute to grant applications and support the supervision and training of students and junior researchers
- Prepare manuscripts and present findings at internal meetings and external conferences
- Utilize advanced facilities and resources for professional development in translational and basic research
Qualifications
- Strong laboratory skills in immunology with experience in experimental design and troubleshooting
- Demonstrated research experience in a relevant field supported by peer-reviewed publications
- Competence in data analysis, including quantitative methods, statistical evaluation, and use of relevant software tools for experimental and imaging data
- Willingness to work in a team and contribute to other projects in the lab
- PhD (or equivalent) in immunology, completed or near completion
- Strong written and verbal communication skills, with the ability to prepare publications, reports, and presentations for diverse audiences
- Ability to work collaboratively in an interdisciplinary environment, manage projects and timelines, and maintain high standards of research integrity and reproducibility
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