RBW Consulting
Principal Clinical Research Associate
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Principal Clinical Research Associate / Principal CRA – Remote, UK
Location: Fully remote with travel across UK
Position type: Permanent
About Our Client
Our client is a well-established clinical research organisation operating within highly regulated environments, supporting complex, international clinical trials. Working across multiple therapeutic areas and trial phases, they focus on high-quality monitoring, balanced performance expectations and clear career pathways for their clinical operations professionals.
Our client’s team is known for promoting from within, supporting long-term careers in clinical research and offering flexible working arrangements that respect work-life balance. You will be joining a collaborative group of CRAs, study managers and operational specialists who share knowledge and support each other across remote locations.
The Opportunity
This is a permanent, fully remote Senior CRA or Principal CRA level depending on your experience and skill set. You will work across a variety of clinical trials and phases without being limited to specific therapeutic areas, giving you broad exposure and the chance to deepen your monitoring expertise.
The role offers a visible pathway for progression, with genuine potential to move quickly through levels based on performance and capability. You will benefit from balanced KPIs, realistic expectations around travel and a supportive structure that focuses on your development rather than simply maximising visit numbers.
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Key Responsibilities
- Conduct independent on-site monitoring visits across UK
- Perform all aspects of routine monitoring activities in line with protocols, SOPs and regulatory requirements across various trial phases.
- Build and maintain strong relationships with site staff to support study conduct, data quality and patient safety.
- Document monitoring activities comprehensively and ensure timely follow-up on action items.
- Collaborate closely with project teams, contributing to study management discussions and resolving site-related issues.
- Demonstrate flexibility around travel and site allocation, understanding that locations may vary according to business needs.
What Makes This Role Attractive
- Clear and visible career progression.
- Balanced KPIs that allow you to focus on quality, development and long-term growth rather than only meeting high visit targets.
- Genuine work-life balance, supported by remote working and thoughtful study allocation.
- Near-site incentives and an approach to site allocation that aims to keep you predominantly within reasonable travelling distance, while recognising that some longer trips may be required.
- Access to peer and buddy programmes, offering mentoring, support and guidance from more experienced colleagues.
- Opportunities to progress into other suitable career pathways, depending on your interests and strengths.
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Skills & Experience Required
- Strong, independent on-site monitoring experience in clinical trials,
- For Principal CRA / Lead CRA consideration, usually 6–8 years’ CRA experience, with a proven track record of handling complex studies and responsibilities.
- Experience across any therapeutic areas and clinical trial phases – there is no requirement for specific indication expertise.
- A valid driving licence and willingness to travel regularly for site visits.
- Life Sciences degree or relevant experience
- Right to work in the UK is essential; our client is unable to offer visa sponsorship.
Is This Role Right For You?
This position will suit you if you are an experienced CRA who values structured progression, realistic monitoring expectations and genuine work-life balance. If you enjoy independent on-site work, want to broaden your exposure across different studies and phases, and are looking for a remote role that still offers strong team connection and support, this could be an excellent next step.
How to Apply
If you meet the criteria outlined and would like to be considered for a CRA II, Senior CRA or Principal CRA level position, please submit your CV. We will review your experience, discuss your career ambitions and guide you through the next steps with our client.
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