Genomics England
Principal Clinician - Genomic Diagnostics (2 Yr FTC Or Secondment) - (We have office locations in Cambridge, Leeds and London)

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Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare. Building on the 100,000 Genomes Project, we support the NHS’s world-first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives. By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future.
Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK’s position as the best place to discover, prove and benefit from genomic innovations.
We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.
Behind the Healthcare and Research outcomes, Genomics England delivers through designing, developing and operating complex healthcare software systems.
We're on the cusp of big changes with the real prospect of genomics becoming the fabric of everyday healthcare through the lifetime – from birth to old age.
Job Description
We are seeking a Principal Clinician – Genomic Diagnostics to join us on a two-year fixed-term contract or external secondment. In this role, you will provide expert clinical leadership and subject matter expertise across key internal workstreams, while influencing the wider genomics ecosystem at both national and international levels. You will play a pivotal role in maximising our impact for participants, patients, and the NHS through the advancement and implementation of genomic diagnostics.
The primary purpose of this role is to work closely with the Healthcare Genomics Service (HGS), advising the service leadership team and supporting squads and teams in planning, developing, and releasing safe, well-researched rare disease and cancer-related diagnostic products and services.
Everyday responsibilities include:
- Provide clinical leadership and expertise in designing and delivering our services and programs.
- Support the Chief Medical Officer, Chief Scientific Officer, Director of External Affairs, and Director of Ethics in engagements with various advisory committees and the Participants Panel.
- Offer clinical support to the service management team, including handling complex conversations with research participants and managing inquiries, complaints, and clinical incidents.
- Play a key role in providing and coordinating clinical input for clinical safety and risk management systems, working closely with the Clinical Safety Officer.
- Represent Genomics England at national and international conferences, meetings, and working groups.
- Act as the clinical liaison with external bodies like BSGM, devolved nations, DHSC, Genomic Laboratory Hubs, and the Genomic Medicine Service Alliance network.
- Support the Chief Medical Officer and GMS Service Owner in collaborations between Genomics England and NHS England/NHS colleagues.
- Define and advocate for priorities relevant to patients and clinicians with the Executive Leadership Team and colleagues across Genomics England.
- Develop strong relationships with senior stakeholders to explain, drive, and advocate for Genomics England initiatives and priorities.
- Provide clinical leadership in evolving research strategy and coordination, and develop processes to support research stakeholders
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For this role, we are seeking a proactive and dynamic clinician with extensive experience in the diagnostic application of genomics within the NHS. The ideal candidate will have a background in oncology, rare disease, or another clinical specialty where genomics plays a central role in diagnosis and clinical decision-making, with strong expertise in clinical safety.
This role requires a clinician who ideally is not only knowledgeable and experienced in, but also passionate about driving advancements in, diagnostic genomics and healthcare informatics, as well as possessing a proven track record in clinical leadership, able to zoom into the detail of our products and processes, and back out into strategic service planning.
Qualifications
Ideally PhD genomics (or alternative genomics experience / qualifications).
Additional Information
Salary from: £93,500
Closing date for applications - Monday 3rd August
Please note: We welcome secondments and encourage applications from individuals with a range of professional backgrounds, including those from the NHS, who bring valuable skills and experience from clinical settings.
Due to the nature of the role, the successful candidate would be required to be based in our Canary Wharf office 1 day per week.
Being an integral part of such a meaningful mission is extremely rewarding in itself, but in order to support our people, we’re continually improving our benefits package. We pride ourselves on investing in our people and supporting them to achieve their career goals, as well as offering a benefits package including:
- Generous Leave: 30 days’ holiday plus bank holidays, additional leave for long service, and the option to apply for up to 30 days of remote working abroad annually (approval required).
- Family-Friendly: Blended working arrangements, flexible working, enhanced maternity, paternity and shared parental leave benefits.
- Pension & Financial: Defined contribution pension (Genomics England double-matches up to 10%, however you can contribute more if you wish), Life Assurance (3x salary), an Electric Vehicle salary sacrifice scheme and a Give As You Earn scheme.
- Learning & Development: Individual learning budgets, support for training and certifications, and reimbursement for one annual professional subscription (approval required).
- Recognition & Rewards: Employee recognition programme and referral scheme.
- Health & Wellbeing: Subsidised gym membership, a free Headspace account, and access to an Employee Assistance Programme, eye tests, flu jabs.


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Equal opportunities and our commitment to a diverse and inclusive workplace
Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, diversity and inclusion best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability, ethnicity, gender, gender identity, religion, sexual orientation, or social background.
Genomics England’s policies of non-discrimination and equity and will be applied fairly to all people, regardless of age, disability, gender identity or reassignment, marital or civil partnership status, being pregnant or recently becoming a parent, race, religion or beliefs, sex or sexual orientation, length of service, whether full or part-time or employed under a permanent or a fixed-term contract or any other relevant factor.
Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work. Such behaviour undermines our mission and core values and diminishes the dignity, respect and integrity of all parties. Our People policies outline our commitment to inclusivity.
We aim to remove barriers in our recruitment processes and to be flexible with our interview processes. Should you require any adjustments that may help you to fully participate in the recruitment process, we encourage you to discuss this with us.
Culture
We have four key behaviours that represent what we would like Genomics England to feel like and the culture we want to encourage, in order for us to achieve our mission. These behaviours help us all work well together, deliver on our outcomes, celebrate our successes and share feedback with each other. You can read about these and other aspects of our culture here Culture | Genomics England
Blended working model
Genomics England operates a blended working model as we know our people appreciate the flexibility that hybrid working can bring. We expect most people to come into the office a minimum of 2 times each month. However, this will vary according to role and will be agreed with your team leader. There is no expectation that people will return to the office full time unless they want to, however, some of our roles require full time on site attendance e.g., lab teams, reception team.
Our teams and squads have, and will continue to reflect on what works best for them to work together successfully and have the freedom to design working patterns to suit, beyond the minimum. Our office locations are: Canary Wharf, Cambridge and Leeds.
Onboarding background checks
As part of our recruitment process, all successful candidates are subject to a Standard Disclosure and Barring Service (DBS) check. We therefore require applicants to disclose any previous offences at point of application, as some unspent convictions may mean we are unable to proceed with your application due to the nature of our work in healthcare.
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