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We are looking for a Principal Scientist, Non-Clinical PKPD, who is innovative and agile to join us in our Clinical Development Sciences Group, based at the R&D site in Slough, UK, then Windlesham, Surrey (2027).
About the role
The Non-Clinical PKPD group sits within the Quantitative Clinical Pharmacology (QCP) function of Early Clinical Development & Translational Science (ECD-TS) Department. Our goal is to use integrated quantitative approaches as an essential strategic driver from target to market to bring differentiated solutions to patients. We are driving the quantitative integrated strategy of pharmacokinetics and pharmacology (e.g. PKPD, Systems modelling and clinical pharmacology/pharmacometrics) together with DMPK activities throughout the entirety of the lifetime of projects, from target identification through to life cycle management.
Who you’ll work with
We operate and collaborate closely with colleagues in Development Sciences, which, as a department, is responsible for providing strategy and support in bioanalysis, immunogenicity, safety, pathology, and regulatory activities. Work with external partners, academic institutions, CROs and consultants as required.
What you’ll do
- Develop and drive the nonclinical PKPD strategy for projects. Communicating effectively ensuring implementation in projects.
- Ensure translation from in vitro data and in vivo nonclinical studies to prediction of efficacy and safety in patients.
- Initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build a thorough knowledge of drug pharmacology and PKPD, leading to quantitative translation to the clinic.
- Build PKPD models of sufficient complexity to allow hypothesis testing and inform decision-making.
- Represent the interests of QCP internally and externally in matters relevant to mechanistic PKPD and contribute to enhancing the scientific reputation of Non-Clinical PKPD, QCP and UCB.
- Provide required support and input into regulatory study protocols, reports and summaries, and regulatory submission documents.
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Interested? For this role you will need the following education, experience and skills
- PhD in relevant discipline (pharmacology, pharmaceutical sciences, pharmacokinetics/pharmacodynamics, system biology or related fields).
- Good understanding of pharmacology and pharmacologic processes related to disease and drug mechanisms.
- Expertise and proven application of PKPD methods and concepts in support of drug discovery and development; systems modelling experience would be advantageous.
- Demonstrated experience in developing and executing effective non-clinical PKPD strategies from early discovery through to clinic.
- Demonstrated experience and leadership skills working within a matrix environment with a wide range of internal stakeholders including Non-Clinical Safety, Bioanalysis, Clinical Pharmacology and Translational Medicine.
- Experience in using modelling and simulation packages such as Phoenix, Berkeley Madonna, R and Monolix.
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Internal applicants
Internal applicants should be in their current job for at least 12 months, must meet performance standards and are not on formal corrective/disciplinary process (PIP), warning, final warning, or compliance warning letters within the last 12 months. Please inform your Manager or your Talent Partner before applying to any internal job opportunities.
UCB
At UCB, we’ve embraced a hybrid-first approach to work, bringing teams together in local hubs to foster collaborative curiosity. Unless expressly stated in the description, this role is hybrid with 40% of your time spent in the office, irrespective of your current contractual agreement. Should your current working arrangements differ, please contact your Talent Partner to discuss, before submitting your application.
UCB is an equal opportunity employer. All employment decisions will be made without regard to any characteristic protected by applicable laws.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on EMEA-Reasonable_Accommodation@ucb.com. Please note should your enquiry not relate to adjustments; we will not be able to support you through this channel.
Additional Information
- Requisition ID: 92379
- Recruiter: Joanna Coombs
- Hiring Manager: Victoria Flores
- Talent Partner: Geraldine Beauduin
- Job Level: MM II
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