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Principal Scientist, Translational Biomarkers and Bioanalysis
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Principal Scientist – Translational Bioanalysis & Biomarkers // Biologics // Oxford
You are an experienced translational scientist working at the interface of bioanalysis, biomarkers, and drug development. You’ve taken biologics through preclinical development and towards the clinic, and you understand what it takes to translate assays into a regulated environment.
You want to own a programme-facing role where you define strategy, not just execute it. You want visibility, influence, and the chance to take a novel molecule into first-in-human studies.
We are partnering with an Oxford-based biotech unlocking new therapeutic targets through deep understanding of 3D genome regulation. As they transition into a clinical-stage company, they are building the translational capability to take their lead biologic into Phase 1. This is a pivotal hire. You will become the internal expert in bioanalysis and biomarkers, owning strategy and delivery for the flagship programme.
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THE ROLE
As Principal Scientist – Translational Bioanalysis & Biomarkers, you will lead the design and execution of biomarker and bioanalytical strategies across preclinical and IND-enabling studies, ensuring readiness for clinical development. You will operate across disciplines, externally with CROs, and internally as the biomarker leader on programme teams.
KEY RESPONSIBILITIES
- Define and implement integrated biomarker strategies (PK, ADA, PD, target engagement, exploratory biomarkers)
- Translate research assays into fit-for-purpose bioanalytical assays in GxP environments
- Own bioanalytical planning for IND/CTA-enabling studies and Phase 1 readiness
- Manage CROs and bioanalytical vendors, including assay development, qualification, transfer, and oversight
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ABOUT YOU
- Strong experience in translational bioanalysis and biomarkers within biotech/pharma
- Proven track record supporting biologics through preclinical and IND-enabling stages
- Strong communicator, able to influence without direct authority
- Collaborative, hands-on, and comfortable operating in a fast-paced biotech environment
LOGISTICS
- Location: Oxford (on-site)
- Level: Principal Scientist
If you want to take ownership of a flagship programme and build translational strategy from preclinical through to clinic, apply here.
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