InvenireX
Research and Development Scientist – Biochemistry and Microfluidics
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About InvenireX
InvenireX is a Deeptech life sciences startup engineering an entirely new class of diagnostic hardware. With VC backing and UKRI support, we're building a platform that:
- Directly counts single DNA/RNA molecules using nano-scale microfluidics, fluorescence imaging, and advanced computer vision algorithms.
- Has been validated and is now being pushed towards commercial readiness.
We’re now hiring a Research and Development scientist to join the core team building out the Biochemistry and microfluidic compatibility of this system.
The Role
This is not an academic post. It’s a hands-on, experimental role where your work will have direct and immediate impact on a commercial product. You’ll lead the charge on refining and validating our core nucleic acid detection assays, and our in-house microfluidic chip fabrication for design prototyping.
- You’ll be working closely with hardware engineers and software engineers to design and optimise our DNA detection system and microfluidic chips for compatibility in our machine prototypes.
This role is ideal for a multi-skilled, resilient, and self-motivated scientist, with a strong work ethic that thrives in the face of a challenge.
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Key Responsibilities
- Design, test, and optimise hybridisation-based nucleic acid assays using magnetic beads and fluorescent probes.
- Create, test, and optimise microfluidic chips in-house to prototype new design variants.
- Conduct systematic experiments to determine hybridisation kinetics, melting curves, and signal linearity.
- Run end-to-end assay protocols, including bead handling, incubation, chip loading, and imaging.
- Develop and refine methods for reducing non-specific binding, autofluorescence, and other background signals.
- Interface closely with hardware/software teams to align assay timing, reader settings, and performance targets.
- Document protocols clearly for internal use and future regulatory readiness.
- Identify bottlenecks and propose innovative solutions for improving assay robustness and turnaround time.
- Work with early users and partners to validate real-world assay performance in diverse contexts.
Essential Experience
- MSc, MRes, or PhD in Biochemistry, Molecular Biology, Bioengineering, or a related field.
- Hands-on experience developing or running DNA/RNA hybridisation assays or other nucleic acid tests (qPCR, LAMP, FISH, etc).
- Comfortable handling oligonucleotides, beads, buffers, and setting up reaction protocols.
- Track record of troubleshooting experimental noise, false positives, or edge-case artefacts.
- Comfortable with quantitative analysis of assay performance (e.g., LoD, specificity, sensitivity, SNR).
- Able to work in a small, multidisciplinary team where every result matters.
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Bonus Experience
- Experience with microfluidics, droplet assays, or femtoliter/picoliter systems.
- Prior work with diagnostic assays, biosensors, or point-of-care systems.
- Knowledge of fluorescence detection methods or single-molecule detection strategies.
- Experience scripting analysis in Python or R.
Your Profile
You’re not just smart—you’re driven to figure out how things work and making them work better.
- You have an experimentalist’s soul: methodical, inventive, persistent, and driven by real-world outcomes.
- You work from first principles and ask the questions others don’t.
- You’ve built things from scratch—kits, protocols, maybe even instruments.
- You want your work to matter—and you want to work somewhere that moves fast and demands the best.
Location
- Newcastle Upon Tyne
Pay
- £34,920.00 per year
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