Newcastle University
Research Technician
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Research Technician – Cancer Research UK Funded Project (Hepatocellular Carcinoma - Fibrosis Research Group)
Salary: £29,588.00 per annum Closing Date: 29 July 2026
Newcastle University offers an inspiring environment with exciting opportunities, excellent benefits, and strong commitment to supporting staff. Learn more about working at Newcastle University.
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About the Role
The Fibrosis Research Group at Newcastle University is seeking a talented Research Technician to support a Cancer Research UK funded project exploring the tumour immune microenvironment in hepatocellular carcinoma (HCC).
The project investigates how metabolic stress and hypoxia reprogramme cancer-associated fibroblasts (CAFs) to drive immune suppression and immunotherapy resistance in HCC—the third leading cause of cancer-related death globally.
The successful candidate will participate in cutting-edge research using pre-clinical human and mouse models, spatial and single-cell technologies, to uncover CAF-driven tumour microenvironment mechanisms and develop novel immunotherapeutic strategies for liver cancer.
Key Responsibilities
The role will involve:
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Supporting laboratory operations across multiple disciplines, including:
- Maintenance of mouse colonies
- Tissue processing and molecular/cellular biology
- Flow cytometry
- Immunohistochemistry (IHC) and immunofluorescence (IF)
- Spatial profiling studies
- Reagent preparation, stock management, and ensuring compliance with biosafety and animal welfare regulations
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Core tasks and responsibilities:
- Managing human and mouse model experiments (initially supervised, then independently)
- Maintaining accurate laboratory records, safety documentation, and compliance data
- Collaborating with suppliers on problem resolution and equipment upgrades
- Supporting library administration, equipment management, and cross-laboratory coordination
- Presenting results to academic leads and research teams
- Overseeing laboratory compliance, training induction, and safety development
- Ensuring colonial and facilities maintenance, alongside research and teaching support
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Role Type
- Fixed-term, 100% FTE, 3-year position (flexible working proposals may be considered)
Contact for Inquires
For informal discussions, contact: Dr Jack Leslie (Jack.Leslie@newcastle.ac.uk)
Discover more about the Faculty of Medical Sciences →
Key Responsibilities & Duties
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Experimental Support:
- Responsible for day-to-day management of human/mouse tissue/cell-based experiments.
- Gain expertise in HCC models, performing experiments under supervision before working independently.
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Record Keeping & Compliance:
- Maintain accurate, secure, and up-to-date laboratory records.
- Liaise with suppliers for problem solving and solutions.
- Update and comply with regulatory safety standards (including animal welfare and biosafety).
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Workflow Organisation & Teamwork:
- Schedule, prioritise, and monitor workload to meet deadlines.
- Represent results to research teams and present findings.
- Monitor resource usage and ensure efficient store management.
- Create and maintain operational procedures for seamless research flow.
Additional Duties (as assigned):
- Provide teaching support within university teaching portfolios.
- Develop and deliver induction training sessions in laboratory techniques.
- Lead troubleshooting efforts and optimise protocols.
- Cover out-of-hours laboratory duties as required.
The Person: Knowledge, Skills & Experience
Essential Qualifications & Experience
- A BTEC HNC/HND or equivalent in biosciences/related field, or equivalent através experience.
- Laboratory technical expertise in at least one of the following areas:
- PCR/Real-Time PCR
- ELISA/Flow Cytometry (desirable)
- Sterile Cell Culture
- Histology/IHC/Immunofluorescence
- Relyable work ethic with demonstrated attention to detail and laboratory safety knowledge.
- Strong teamwork ability.
- Ability to manage multiple projects under pressure.
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Desirable Skills
- Flow cytometry experience or single-cell technologies exposure.
- Experience with safety documentation and equipment calibration for research use.
- Volunteer/training program participation or professional teaching/mentoring.
- Registration/working towards professional accreditation (e.g., HEA in science).
Attributes & Behaviour
- Enthusiastic about cancer biology/liver diseases and committed to skills development.
- Strong oral/written communication and collaborative work demeanour.
- Adaptability to changing research priorities and problem-solving aptitude in science.
- Commitment to inclusivity, fairness, and University principles.
Qualifications
Essential
- Equivalent to BTEC HNC/HND in biosciences or relevant field, or appropriate laboratory experience.
Desirable
- A Bachelor’s degree in a related discipline (e.g., Molecular Biology, Immunology).
- Membership or map towards professional body registration (e.g., HEA trainee status).
- Prior experience directing teams or materials logistics in research environments.
Newcastle University Mission & Principles
As a global institution, we prioritise diversity, inclusivity, and a welcoming environment for all.
- Sanctuary University Status: We provide refuge and opportunities to those fleeing persecution.
- Equal Opportunities Employer: We celebrate workplace diversity and believe success lies in varied skills.
- Accreditation: Respected for:
- 39 year as part of Euraxess (researchers across Europe).
- Gold Athena Swan Award for advancing gender equality.
- Race Equality Charter (Bronze Award).
- Disability Confident employer, offering access to those with disabilities.
- Commitment: Ensuring fairness for everyone, including preference for diverse experience in roles.
Apply now at Newcastle University → | Requisition ID 29527
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